具有抗菌和再矿化特性的新型含氟石墨/生物活性玻璃正畸底漆:体外研究

Afaf H Hussein, Yassir A Yassir
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引用次数: 0

摘要

目的:本研究旨在开发一种含有氟化石墨(GF)和生物活性玻璃(BAG)的新型正畸底漆,并研究其细胞活力、粘接强度和牙釉质损伤,以及抗菌和再矿化特性:在 Transbond™ XT 正畸底漆中添加不同浓度的 GF(1、2 和 4 wt.%)和 BAG(1、3 和 5 wt.%),制备九组底漆。将制备的底涂与对照底涂在细胞活力、剪切粘接强度(SBS)、粘接残留指数(ARI)、釉质损伤指数(EDI)和抗菌测试方面进行了比较。然后,对抗菌性能较好的组别(GFBAG 1-1、GFBAG 4-1、GFBAG 4-3、GFBAG 4-5)进行再矿化性能评估:结果:所有使用不同浓度 GF/BAG 制备的正畸引物都显示出可接受的细胞活力水平,其 SBS 和 ARI 值与对照引物相当(p>0.05)。同时,与对照组相比,EDI 降低了,而抗菌性能则明显增强(p0.05)。再矿化性能结果显示,所选组的再矿化能力明显高于对照组;这在 GFBAG 4-3 组最为明显:所有制备的 GF/BAG 正畸底漆都是生物安全的,具有足够的 SBS、ARI 和 EDI 值,可用于临床应用,并具有更强的抗菌性能。GFBAG 4-3 实验性底漆具有最佳的抗菌和再矿化特性,需要进一步进行体外和体内研究,以作为白斑病变的预防措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Graphite Fluoride/Bioactive Glass-containing Orthodontic Primer with Antibacterial and Remineralization Properties: An In-vitro Study.

Purpose: This study aimed to develop a novel orthodontic primer that incorporated graphite fluoride (GF) and Bioactive glass (BAG) and to investigate its cell viability, bonding strength, and enamel damage, as well as its antibacterial and remineralization properties.

Materials and methods: Nine groups were prepared by adding different concentrations of GF (1, 2, and 4 wt.%) and BAG (1, 3, and 5 wt.%) to Transbond™ XT orthodontic primer. The prepared primers were compared to the control primer in terms of cell viability, shear bond strength (SBS), adhesive remnant index (ARI), enamel damage index (EDI), and antibacterial test. Then, the groups with better antibacterial properties (GFBAG 1-1, GFBAG 4-1, GFBAG 4-3, GFBAG 4-5) were evaluated for the remineralization properties.

Results: All the prepared orthodontic primers with different concentrations of GF/BAG revealed acceptable cell viability levels, with comparable SBS and ARI values to the control primer (p>0.05). Simultaneously, the EDI was reduced, while the antibacterial properties were significantly enhanced when compared to the control group (p0.05). The result of remineralization properties revealed that the selected groups had significantly higher remineralization ability than the control group; this was most pronounced in the GFBAG 4-3 group.

Conclusions: All the prepared GF/BAG orthodontic primers are biologically safe with adequate SBS, ARI, and EDI values for clinical application with enhanced antibacterial properties. The GFBAG 4-3 experimental primer reveals the best antibacterial and remineralization properties which require further in-vitro and in-vivo investigations as a preventive measure of white spot lesions.

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