铜失衡及其与 AMPK 激活、线粒体动力学和线粒体生物生成的关系：体内研究的系统回顾。

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-10-11 DOI:10.1016/j.jtemb.2024.127549

Sarah Maria van Tol Amaral Guerra , Letícia Cordeiro Koppe de França , Katriane Neto da Silva, Fabielly Scolari Grotto, Viviane Glaser

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引用次数: 0

摘要

导言：铜失衡可能与铜含量增加有关，导致中毒；也可能与组织中铜含量减少有关，损害铜酵素的活性。在细胞内，铜可在细胞质和细胞器内找到，而线粒体是将铜分隔开来的主要细胞器。这种细胞器可以形成网络，并可能从中融合或裂变，分别决定了线粒体的融合和裂变过程。线粒体融合和裂变（称为线粒体动力学）与线粒体自噬（线粒体自噬）和线粒体生物生成一起，决定了细胞中线粒体的数量。线粒体动力学和新线粒体生物生成的主要调节器是 AMPK。考虑到铜水平的降低和升高都会影响线粒体的更替，尤其是在与铜平衡失调有关的疾病中，本系统综述的目的是验证目前有关铜平衡对体内 AMPK 激活、线粒体动力学和新线粒体生物生成的影响的知识：方法：使用 PubMed (MEDLINE)、Embase 和 Web of Science 数据库搜索文献中的文章。方法：使用 PubM（MEDLINE）、Embine 和 Web Science 数据库搜索文献，提取铜水平降低或升高对参与线粒体动力学或生物生成的蛋白质表达影响的相关数据，以及 AMPK 和 p-AMPK 水平的相关数据：元分析表明，高铜水平会增加线粒体裂变，抑制线粒体融合。此外，铜含量的增加会导致 AMPK 激活。很少有研究分析了高铜含量对线粒体生物生成相关蛋白质的影响，以及铜含量降低对线粒体动力学和生物生成以及 AMPK 激活的影响：尽管本综述收集了一些结果，但要完全了解铜在调节 AMPK 激活、线粒体动力学和新线粒体生物生成中的作用，还需要进行其他研究，因为细胞对铜失衡的反应可能因分析的物种和组织而异。

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Copper dyshomeostasis and its relationship to AMPK activation, mitochondrial dynamics, and biogenesis of mitochondria: A systematic review of in vivo studies

Introduction

Copper dyshomeostasis can be related to an increase in copper levels, resulting in toxicity, or to a decrease in tissues levels, impairing cuproenzyme activities. Inside cells, copper can be found in the cytoplasm and inside organelles, and the main organelle that compartmentalizes copper is the mitochondrion. This organelle can form networks and may fuse or fission from this, determining the mitochondrial fusion and fission processes, respectively. Together with mitophagy (autophagy of mitochondria) and mitochondrial biogenesis, mitochondrial fusion and fission (denominated mitochondrial dynamics) determine the number of mitochondria in a cell. A master regulator of mitochondrial dynamics and biogenesis of new mitochondria is AMPK. Considering that both a decrease and an increase in copper levels can influence mitochondrial turnover, especially in diseases related to copper dyshomeostasis, the objective of this systematic review was to verify the current knowledge on the influence of copper homeostasis on AMPK activation, mitochondrial dynamics, and biogenesis of new mitochondria in vivo.

Methods

PubMed (MEDLINE), Embase, and Web of Science databases were used to search for articles in the literature. Data about the effects of a decrease or an increase in copper levels on the expression of proteins involved in mitochondrial dynamics or biogenesis, and data about AMPK and p-AMPK levels were extracted.

Results

Meta-analysis has demonstrated that high copper levels increase mitochondrial fission and inhibit mitochondrial fusion. Additionally, an increase in copper levels results in AMPK activation. Few studies have analyzed the effects of high copper levels on proteins related to mitochondrial biogenesis, as well as the impact of a decrease in this metal on mitochondrial dynamics and biogenesis, and on AMPK activation.

Conclusions

Despite the results gathered in this review, other studies are necessary to completely understand the role of copper in regulating AMPK activation, mitochondrial dynamics, and the biogenesis of new mitochondria, since the cell response to a copper dyshomeostasis could be different depending on the species and tissues analyzed.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.