Tatsuya Tada, Satoshi Oshiro, Naeko Mizutani, Koji Sato, Nang Sarm Hom, Pan Ei Soe, Thi Thi Htoon, Htay Htay Tin, Teruo Kirikae
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引用次数: 0
摘要
2017 年 2 月至 2021 年 1 月期间，从缅甸三个医疗机构的住院病人身上分离到了七株耐药伊丽莎白金丝菌。所有分离株均对β-内酰胺类药物和可乐定产生耐药性。其中，四个分离株对阿米卡星耐药，最低抑菌浓度（MIC）≥64 µg ml-1。7 个分离株中有 6 个携带有编码固有 β-内酰胺酶的基因，包括 bla B、bla CME 和 bla GOB，而 1 个分离株携带有 bla B、bla CME 和不完整的 bla GOB 基因。基于全基因组序列的系统发育分析表明，缅甸的几种阿诺菲氏菌分离物形成了自己的集群，而其他分离物则与美国的分离物相似。这是缅甸首次报道出现伊丽莎白金格氏菌物种。
Emergence of drug-resistant Elizabethkingia anophelis clinical isolates in Myanmar.
Seven drug-resistant Elizabethkingia anophelis isolates were obtained from inpatients in three medical settings in Myanmar between February 2017 and January 2021. All isolates were resistant to β-lactams and colistin. Among these, four isolates were resistant to amikacin with minimum inhibitory concentration (MIC) of ≥64 µg ml-1. Six of the seven isolates harboured genes encoding intrinsic β-lactamases, including blaB, blaCME and blaGOB, whereas one isolate harboured blaB, blaCME and an incomplete blaGOB gene. Phylogenetic analysis based on whole-genome sequences revealed that several E. anophelis isolates in Myanmar formed their own clusters, whereas others were similar to isolates found in the USA. This is the first report of the emergence of Elizabethkingia species in Myanmar.
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