骨内植入生物材料后的骨免疫调节研究进展:关注表面亲水性。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Xinpeng Wei, Linshan Lei, Ling Luo, Ying Zhou, Zheng Zheng and Wenchuan Chen
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引用次数: 0

摘要

用于骨内植入的生物材料广泛应用于整形外科和牙科领域。它们的表面特性,尤其是亲水性,会对植入物周围的生物相互作用产生重大影响,最终决定植入物在体内的命运。最近,人们认识到骨免疫调节在这些植入式生物材料中的作用,因为它在调节生物材料介导的成骨过程中起着重要作用。因此,必须阐明亲水性与免疫反应之间的相关性,以开发骨免疫调节植入物。在此,本综述从表面亲水性这一新视角出发,重点介绍了骨内植入生物材料后骨免疫调节的最新进展,并总结了亲水性植入物所引起的一系列免疫反应和随后的骨重塑,重点介绍了蛋白质吸附、主要免疫细胞的行为以及骨免疫调节促进的血管生成和骨生成。亲水性生物材料有能力改变周围的免疫微环境,加速材料与组织的结合过程,从而促进生物材料与组织的成功整合。总之,作者希望这篇文章能提供调节亲水性以实现骨免疫调节性能的策略,并进一步促进骨科和牙科应用中新型植入式生物材料的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances in osteoimmunomodulation of biomaterials after intrabone implantation: focus on surface hydrophilicity

Advances in osteoimmunomodulation of biomaterials after intrabone implantation: focus on surface hydrophilicity

Biomaterials intended for intrabone implantation are extensively utilized in orthopedic and dental applications. Their surface properties, particularly hydrophilicity, significantly influence the biological interactions surrounding the implant, ultimately determining the implant's in vivo fate. Recently, the role of osteoimmunomodulation in these implantable biomaterials has been recognized for its importance in regulating biomaterial-mediated osteogenesis. Consequently, it is imperative to elucidate the correlation between hydrophilicity and the immune response for the development of osteoimmunomodulatory implants. Herein, this review highlights recent advances in osteoimmunomodulation of biomaterials after intrabone implantation from a novel perspective—surface hydrophilicity, and summarizes the series of immune reactions and subsequent bone remodeling that occur in response to hydrophilic implants, focusing on protein adsorption, the behaviors of major immune cells, and osteoimmunomodulation-enhanced angiogenesis and osteogenesis. Hydrophilic biomaterials have the capacity to alter the surrounding immune microenvironment and accelerate the process of material-tissue bonding, thereby facilitating the successful integration of biomaterials with tissue. Collectively, the authors hope that this article provides strategies for modulating hydrophilicity to achieve osteoimmunomodulatory performance and further promotes the development of novel implantable biomaterials for orthopedic and dental applications.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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