调整界面分子不对称,设计出具有卓越表面锚固、防污和抗菌性能的保护涂层。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Yuhao Zhang , Jiawen Zhang , Qiang Yang , Yao Song , Mingfei Pan , Yajing Kan , Li Xiang , Mei Li , Hongbo Zeng
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引用次数: 0

摘要

集生物相容性、防污和抗菌特性于一身的多功能坚固保护涂层在减少侵入性医疗器械的宿主反应和感染方面发挥着至关重要的作用。然而,这些保护涂层的开发通常面临着一个悖论:能够通过自发沉积实现与基底牢固附着的涂层材料不可避免地会引发持续的生物污垢吸附,而那些采用强水合能力来抵御生物污垢附着的涂层材料在磨损情况下的基底结合能力和耐久性有限。在此,我们设计了一种聚(多巴胺甲基丙烯酰胺-2-甲基丙烯酰氧乙基磷酰胆碱-2-(二甲基氨基)-甲基丙烯酸乙酯)(P(DMA-co-MPC-co-DMAEMA))的多功能三元共聚物,它集成了所需的但传统上不兼容的功能(即强大的粘附性、防污性、润滑性和抗菌性)。通过直接法向力和侧向力测量、动态吸附测试、表面离子传导图,全面研究了涂层与生物污泥相互作用的纳米力学。DMA 的儿茶酚基团可作为基底锚定物,实现基底的稳固沉积,而 MPC 的高水合齐聚物可提供顶端保护,抵御生物污损和磨损。此外,DMAEMA 上的叔胺基团通过质子化作用产生抗菌特性,从而抑制生理条件下的感染。这项研究提供了一种有效的策略,在一种涂层材料中协调了所需的但不相容的特性,对开发多功能表面以促进侵入性生物医学设备的发展具有重要意义。意义说明:多功能坚固保护涂层已被广泛应用于侵入性医疗器械中,以减轻宿主反应和感染。然而,改性表面涂层往往需要在与基底的强附着力和强水合能力之间进行权衡,以获得防污和抗菌性能。我们提出了一种通过多巴胺辅助共沉积 P(DMA-co-MPC-co-DMAEMA)多功能三元共聚物进行表面改性的通用策略,可同时实现强大的附着力、防污和抗菌性能。通过阐明纳米力学并从根本上了解涂层与生物大分子之间的相互作用,我们强调了 DMA 在基底粘附、MPC 在生物防污以及 DMAEMA 在抗菌活性方面的作用。这种方法通过调整界面分子不对称性来调和同一涂层中不相容的特性,为在微创医疗器械上构建多功能涂层提供了一种前景广阔的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tuning interfacial molecular asymmetry to engineer protective coatings with superior surface anchoring, antifouling and antibacterial properties

Tuning interfacial molecular asymmetry to engineer protective coatings with superior surface anchoring, antifouling and antibacterial properties
Multifunctional robust protective coatings that combine biocompatibility, antifouling and antimicrobial properties play an essential role in reducing host reactions and infection on invasive medical devices. However, developing these protective coatings generally faces a paradox: coating materials capable of achieving robust adhesion to substrates via spontaneous deposition inevitably initiate continuous biofoulant adsorption, while those employing strong hydration capability to resist biofoulant attachment have limited substrate binding ability and durability under wear. Herein, we designed a multifunctional terpolymer of poly(dopamine methyacrylamide-co-2-methacryloyloxyethyl phoasphorylcholine-co-2-(dimethylamino)-ethyl methacrylate) (P(DMA-co-MPC-co-DMAEMA)), which integrates desired yet traditionally incompatible functions (i.e., robust adhesion, antifouling, lubrication, and antimicrobial properties). Direct normal and lateral force measurements, dynamic adsorption tests, surface ion conductance mapping were applied to comprehensively investigate the nanomechanics of coating-biofloulant interactions. Catechol groups of DMA act as basal anchors for robust substrate deposition, while the highly hydrated zwitterion of MPC provides apical protection to resist biofouling and wear. Moreover, the antimicrobial property is conferred through the protonation of tertiary amine groups on DMAEMA, inhibiting infection under physiological conditions. This work provides an effective strategy for harmonizing demanded yet incompatible properties in one coating material, with significant implications for the development of multifunctional surfaces towards the advancement of invasive biomedical devices.

Statement of significance

Multifunctional robust protective coatings have been widely utilized in invasive medical devices to mitigate host responses and infection. However, modified surface coatings often encounter a trade-off between robust adhesion to substrates and strong hydration capability for antifouling and antimicrobial properties. We propose a universal strategy for surface modification by dopamine-assisted co-deposition with a multifunctional terpolymer of P(DMA-co-MPC-co-DMAEMA) that simultaneously achieves robust adhesion, antifouling, and antimicrobial properties. Through elucidating the nanomechanics with fundamentally understanding the interactions between the coating and biomacromolecules, we highlight the role of DMA for substrate adhesion, MPC for biofouling resistance, and DMAEMA for antimicrobial activity. This approach presents a promising strategy for constructing multifunctional coatings on minimally invasive medical devices by tuning interfacial molecular asymmetricity to reconcile incompatible properties within one coating.
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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