门诊选择性足踝手术患者的静脉血栓栓塞 谁有风险?

Kevin Y Heo, Anthony Karzon, Wesley Manz, Rishin J Kadakia, Jason T Bariteau, Michelle M Coleman
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引用次数: 0

摘要

背景: 静脉血栓栓塞症(VTE)是足踝择期手术后一种罕见但潜在的严重并发症。目前还没有关于择期手术中血栓预防的指南,这凸显了识别高危患者的重要性。本研究旨在确定接受足踝(F&A)择期手术的患者发生 VTE 的主要风险因素。 研究方法 从 IBM MarketScan 数据库(2009-2019 年)中收集年龄大于 18 岁、既往无 VTE 并接受择期足踝手术患者的数据。根据手术区域(前足、中/后足、小腿/脚踝)将患者分为三组。术后 30 天和 90 天记录 VTE 发生率(包括深静脉血栓和/或肺栓塞)。通过多变量逻辑回归确定了 VTE 的风险因素。 结果: 在接受择期 F&A 手术的 301 256 名患者中,90 天内 VTE 的总体发生率为 0.95%。研究结果显示,31.9%的 VTE 事件发生在术后 2 周内,29.2%在 6 周后仍有发生。对手术解剖区域的分析表明,前足手术患者的 90 天 VTE 发生率最低(0.70%)。接受中足/后足手术(1.22%,OR = 1.81)和小腿/脚踝手术(1.76%,OR = 2.31)的患者发生 VTE 的风险较高。VTE的其他风险因素包括血栓性疾病(4.02%,OR = 3.37)、男性(1.30%,OR = 1.47)、年龄增长(1.02%年龄在65岁以上,OR = 1.41)和Charlson综合指数高(1.12%,OR<0.82): 本研究确定了择期 F&A 手术后 VTE 的发生率和时间。此外,本研究还确定了与择期 F&A 手术后 VTE 发生几率增加相关的风险因素。这些研究结果有助于教育患者在术后 90 天及以后仍有发生 VTE 的风险。这些结果还可用于根据个体风险水平对需要进行血栓预防的患者进行分层。 证据等级:III级:回顾性队列研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Venous Thromboembolism in Outpatient Elective Foot and Ankle Procedure Patients Who Is at Risk?

Background: Venous thromboembolism (VTE) is a rare but potentially serious complication following elective foot and ankle (F&A) procedures. The absence of guidelines for thromboprophylaxis in elective procedures underscores the importance of identifying patients at risk. This study aimed to identify key risk factors of VTE in patients who underwent elective foot and ankle (F&A) operations.

Methods: Data was collected from the IBM MarketScan Database (2009-2019) for patients >18 years old without prior VTE who underwent elective F&A procedures. Patients were divided into 3 groups based on region of operation (forefoot, mid/hindfoot, lower leg/ankle). VTE incidence (including deep vein thrombosis and/or pulmonary embolism) was recorded 30 and 90 days postprocedure. Risk factors for VTE were identified through multivariate logistic regression.

Results: Among the 301 256 patients who underwent elective F&A procedures, the overall 90-day incidence of VTE was 0.95%. The findings revealed that 31.9% of VTE incidents occurred within the first 2 weeks after operation, and 29.2% still occurred after 6 weeks. Analysis of the anatomical region of operation demonstrated that the lowest rate of 90-day VTE was amongst patients undergoing forefoot procedures (0.70%). There was a higher risk for VTE in patients undergoing midfoot/hindfoot procedures (1.22%, OR = 1.81) and lower leg/ankle procedures (1.76%, OR = 2.31). Additional risk factors for VTE included thrombophilia (4.02%, OR = 3.37), male sex (1.30%, OR = 1.47), increasing age (1.02% age 65+, OR = 1.41), and a high Charlson Comorbidity Index (1.12%, OR < 0.82 for scores <5).

Conclusion: This study identifies the incidence and timing for VTE after elective F&A procedures. Furthermore, this study defines the risk factors associated with increased odds of VTE after elective F&A procedures. These findings are helpful in educating patients about a continued risk for VTE throughout the 90-day postoperative period and beyond. These results can also be utilized to stratify patients who need thromboprophylaxis based on the individual risk level.

Level of evidence: Level III: Retrospective cohort study.

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