具有光热纳米载体封装的丝纤维微球用于抗癌药物输送。

Changsheng Lu, Runqing Shen, Xiao Wang
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引用次数: 0

摘要

药物控释系统对优化治疗效果和减轻治疗方案的副作用至关重要。虽然脂质体、微/纳米颗粒和微球等传统给药载体很有效,但它们在药物释放率的一致性方面往往存在问题。为了解决这些问题,本研究将刺激响应元件(特别是磁响应、热响应和 pH 响应元件)整合到给药系统中,以实现精确控制。我们的方法的核心是使用蚕丝纤维素(SF),选择它是因为它具有优异的生物相容性和可调降解动力学。我们利用定制设计的微流体平台,将多巴胺纳米颗粒(PDA NPs)嵌入蚕丝纤维微球(SFMs),从而开发出均匀的载体微球(CMs)。本文详细介绍了这一平台的开发过程和应用,突出强调了可实现的精确控制。这些 CMs 展示了增强的光热效应,其热响应可通过改变 PDA NPs 浓度进行微调,在 7.4 wt% 浓度时,温度显著升高 24.5°C。在近红外照射(NIR)条件下,药物负载能力(7.5%)和包封效率(91.6%)都很高,同时还具有 pH 值响应的释放曲线,这为使用模型药物盐酸多柔比星(DOX-HCl)的靶向抗癌药物递送系统铺平了道路。这些发现强调了所开发的微球具有局部外用的潜力,为利用载药微球进行癌症靶向治疗提供了广阔的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Silk fibroin microspheres with photothermal nanocarrier encapsulation for anticancer drug delivery.

Controlled drug release systems are pivotal in optimizing therapeutic outcomes and mitigating side effects in treatment protocols. While traditional delivery vectors such as liposomes, micro/nanoparticles, and microspheres are effective, they often struggle with consistency in drug release rates. This study addresses these issues by integrating stimuli-responsive elements specifically magnetic, thermal, and pH-responsive components into drug delivery systems for precise control. Central to our approach is the use of silk fibroin (SF), chosen for its superior biocompatibility and tunable degradation kinetics. We developed uniform carrier microspheres (CMs) by embedding polydopamine nanoparticles (PDA NPs) into SF microspheres using a custom-designed microfluidic platform. The development process and the application of this platform are detailed, highlighting the precision in control achievable. These CMs showcased enhanced photothermal effects, with the thermal response finely adjustable by altering the PDA NPs concentration, achieving a notable temperature increase of 24.5°C at 7.4 wt% concentration. High drug loading capacity (7.5%) and encapsulation efficiency (91.6%) were achieved, along with a pH-responsive release profile under near-infrared irradiation, paving the way for targeted anticancer drug delivery systems using the model drug doxorubicin hydrochloride. These findings underscore the potential of the developed CMs for external topical application, offering promising prospects for targeted cancer therapy utilizing drug-loaded microspheres.

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