COVID-19 大流行干预措施对法国婴儿意外猝死发生率的影响。

IF 3.9 2区医学 Q1 PEDIATRICS

Journal of Pediatrics Pub Date : 2024-10-19 DOI:10.1016/j.jpeds.2024.114369

Pauline Scherdel PhD , Adeline Ricard MD , Christèle Gras-le Guen MD, PhD , Bérengère Jarry RN , Léa Ferrand MSc , Karine Levieux MD , Naïm Ouldali MD , Sophie de Visme MSc , Camille Aupiais MD, PhD

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引用次数: 0

摘要

目的研究设计：研究在COVID-19大流行期间实施的非药物干预措施（NPIs）对婴儿意外猝死（SUDI）病例总数以及病毒或细菌鉴定病例的月发病率的影响：我们利用法国国家前瞻性多中心SUDI登记处的季节调整泊松回归模型进行了间断时间序列分析，其中包括2016年至2021年期间在法国本土死亡的所有1岁以下SUDI病例：在分析的998例SUDI病例中，750例记录在大流行前（2016年1月至2020年3月），248例记录在NPI期间（2020年4月至2021年12月）。我们发现，SUDI 的月总体发病率具有明显的季节性特征，11 月至次年 2 月为周期性高峰。从大流行前到非大流行期间，SUDI 的月发病率明显下降（调整后的发病率比值为 0.83 [95% 置信区间为 0-72-0-96]）。特别是，经病毒或细菌鉴定的 SUDI 病例的月发病率有所下降，而未经病毒或细菌鉴定的 SUDI 病例的发病率则无明显差异：结论：NPI 与经病毒或细菌鉴定的 SUDI 病例发生率的显著变化有关。需要进一步调查分析病毒和细菌在 SUDI 中的病理生理作用。

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Impact of COVID-19 Pandemic Interventions on Sudden Unexpected Death in Infancy Incidence in France

Objective

To study the impact of nonpharmaceutical interventions implemented during the COVID-19 pandemic on the monthly incidence of sudden unexpected death in infancy (SUDI) cases overall and those with a viral or bacterial identification.

Study design

We conducted an interrupted time-series analysis using seasonally adjusted Poisson regression models from the French national prospective and multicenter SUDI registry, that included all SUDI cases below the age of 1 year who died from 2016 to 2021 in mainland France.

Results

Of 998 SUDI cases analyzed, 750 were recorded during the prepandemic period (January 2016 through March 2020) and 248 during the NPI period (April 2020 through December 2021). We found a significant seasonal pattern of overall monthly SUDI incidence, with a peak observed periodically from November to February. The monthly SUDI incidence decreased significantly from the prepandemic to NPI periods (adjusted incidence rate ratio 0.83 [95% CI 0.72-0.96]). In particular, the monthly incidence of SUDI cases with a viral or bacterial identification decreased significantly, while no significant difference was found for SUDI cases without a viral or bacterial identification.

Conclusions

Nonpharmaceutical interventions were associated with a significant change in the incidence of SUDI cases with a viral or bacterial identification. Further investigations are needed to analyze the pathophysiologic role of viruses and bacteria in the SUDI.

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来源期刊

Journal of Pediatrics 医学-小儿科

CiteScore

6.00

自引率

2.00%

发文量

696

审稿时长

31 days

期刊介绍： The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents. The Journal publishes original work based on standards of excellence and expert review. The Journal seeks to publish high quality original articles that are immediately applicable to practice (basic science, translational research, evidence-based medicine), brief clinical and laboratory case reports, medical progress, expert commentary, grand rounds, insightful editorials, “classic” physical examinations, and novel insights into clinical and academic pediatric medicine related to every aspect of child health. Published monthly since 1932, The Journal of Pediatrics continues to promote the latest developments in pediatric medicine, child health, policy, and advocacy. Topics covered in The Journal of Pediatrics include, but are not limited to: General Pediatrics Pediatric Subspecialties Adolescent Medicine Allergy and Immunology Cardiology Critical Care Medicine Developmental-Behavioral Medicine Endocrinology Gastroenterology Hematology-Oncology Infectious Diseases Neonatal-Perinatal Medicine Nephrology Neurology Emergency Medicine Pulmonology Rheumatology Genetics Ethics Health Service Research Pediatric Hospitalist Medicine.