立体定向体放射治疗肝转移瘤：国际立体定向放射外科协会（ISRS）实践指南的系统回顾和荟萃分析。

IF 3.4 3区医学 Q2 ONCOLOGY

Practical Radiation Oncology Pub Date : 2025-03-01 DOI:10.1016/j.prro.2024.09.011

Ciro Franzese MD , Alexander V. Louie MD, PhD , Rupesh Kotecha MD , Zhenwei Zhang PhD , Matthias Guckenberger MD , Mi-Sook Kim MD , Alison C. Tree MD(Res) , Ben J. Slotman MD, PhD , Arjun Sahgal MD , Marta Scorsetti MD

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引用次数: 0

摘要

目的：肝转移瘤是癌症治疗中的一个重大临床挑战，通常是仍有可能进行根治性治疗的疾病阶段。立体定向体放射治疗（SBRT）是治疗肝转移瘤的一种很有前途的方法，它是一种无创方法，具有很高的疗效。本系统综述和荟萃分析全面分析了SBRT治疗肝转移瘤的疗效和安全性，并提供了实践建议。方法和材料：我们按照系统综述和荟萃分析首选报告项目的方法进行了全面的文献综述，纳入了33项研究，共有3101名患者和4437例肝转移瘤：综述显示，1、2、3年的局部控制（LC）率分别为85%、75%和68%，总生存（OS）率分别为79%、54%和37%。只有 3% 的患者出现 3 级和 4 级副作用。研究综述强调了原发肿瘤组织学、病灶特征和放射剂量等因素在预测治疗结果方面的重要性。结论：本综述支持越来越多的证据表明，SBRT 是一种有效、安全的肝转移治疗方案。它强调了谨慎选择患者和制定个性化治疗计划以优化疗效的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Stereotactic Body Radiation therapy for Liver Metastases: Systematic Review and Meta-Analysis With International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines

Purpose

Liver metastases are a significant clinical challenge in cancer management, often representing a stage of disease in which curative treatment is still possible. Stereotactic body radiation therapy (SBRT) has emerged as a promising modality for treating these metastases, offering a noninvasive approach with potential for high efficacy. This systematic review and meta-analysis provides a comprehensive analysis of the efficacy and safety of SBRT in treating liver metastases, and practice recommendations are provided.

Methods and Materials

We performed a thorough literature review, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach, and included 33 studies with a total of 3101 patients and 4437 liver metastases.

Results

The review revealed pooled local control rates at 1, 2, and 3 years of 85%, 75%, and 68% respectively, while overall survival rates were 79%, 54%, and 37%. Grade 3 and 4 side effects occurred in only 3% of patients. The review of the studies highlighted the importance of factors such as primary tumor histology, lesion characteristics, and radiation dose in predicting treatment outcomes.

Conclusions

This review supports the growing body of evidence that SBRT is an efficacious and safe treatment option for liver metastases. It underscores the need for careful patient selection and personalized treatment planning to optimize outcomes.

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来源期刊

Practical Radiation Oncology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.20

自引率

6.10%

发文量

177

审稿时长

34 days

期刊介绍： The overarching mission of Practical Radiation Oncology is to improve the quality of radiation oncology practice. PRO''s purpose is to document the state of current practice, providing background for those in training and continuing education for practitioners, through discussion and illustration of new techniques, evaluation of current practices, and publication of case reports. PRO strives to provide its readers content that emphasizes knowledge "with a purpose." The content of PRO includes: Original articles focusing on patient safety, quality measurement, or quality improvement initiatives Original articles focusing on imaging, contouring, target delineation, simulation, treatment planning, immobilization, organ motion, and other practical issues ASTRO guidelines, position papers, and consensus statements Essays that highlight enriching personal experiences in caring for cancer patients and their families.