重新考虑味精对健康的影响:从工作台到床边的证据。

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Godswill J Udom, Babatunde R Abdulyekeen, Maryann O Osakwe, Anthonet N Ezejiofor, Chinna N Orish, Fortune C Orish, Chiara Frazzoli, Orish E Orisakwe
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引用次数: 0

摘要

谷氨酸一钠(味精)是一种食品添加剂,可提高食品的适口性,因此在国内和工业上被频繁使用。根据接触味精的剂量系数、频率和持续时间,味精可能会对动物和人类的健康造成不良影响。本报告旨在全面分析经科学证实的味精对健康的不良影响。为实现这一目标,我们采用了 PRISMA 指南和核对表,并检索了 2014 年至 2024 年期间的四个数据库(Scopus、Web of Science、PubMed 和 Google Scholar)。我们使用 ARRIVE 和 Joanna Briggs (JB) 检查表对检索到的研究论文进行了严格的质量评估,并通过叙事综合法进行了数据分析。我们的分析表明,虽然一般认为低剂量的味精是安全的,但高剂量和反复接触味精与胚胎毒性和致畸性、肥胖、心脏毒性、肝毒性、肾毒性、神经毒性、内皮功能障碍、生殖毒性、脂质和葡萄糖代谢的改变有关。因此,长期接触味精可能会对人体产生重要的病理影响。本综述的研究结果为就这种广泛使用的食品添加剂的使用和标签问题做出知情决定提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reconsideration of the health effects of monosodium glutamate: from bench to bedside evidence.

Monosodium glutamate (MSG) is a food additive that enhances the palatability of foods, thus its frequent use both domestically and industrially. Based on the dose-factor, frequency, and duration of exposure, MSG may provoke adverse health outcomes both in animals and humans. The present report aims at providing a comprehensive analysis of the scientifically proven untoward health effects of MSG. To achieve our aim, we adopted the PRISMA guidelines and checklist and searched four databases (Scopus, Web of Science, PubMed, and Google Scholar) from 2014 to 2024. Retrieved research papers were critically appraised for quality using the ARRIVE and Joanna Briggs (JB) checklists and data analysis was conducted via the narrative synthesis method. Our analysis reveals that though MSG is generally considered safe at low doses; however, high doses and repeated exposure to MSG are associated with embryotoxicity and teratogenicity, obesity, cardiotoxicity, hepatotoxicity, kidney toxicity, neurotoxicity, endothelial dysfunction, reproductive toxicities, alteration of lipid, and glucose metabolism. Thus, chronic exposure to MSG may be of human pathological importance. The findings of the present narrative synthesis provide a rationale for informed decisions on the use and labeling of this widely used food additive.

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CiteScore
4.60
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