Paul Studenic, Yvette Meissner, Lianne Kearsley-Fleet, Diederik De Cock
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引用次数: 0
摘要
类风湿性关节炎（RA）是最常见的风湿性疾病之一，在多个方面影响着患者的生活质量。过去三十年来，在治疗方面取得了重大突破，使患者受益匪浅。随着新型治疗方案的不断增加，临床登记处也随之建立并不断发展，以描述患者特征、监测 RA 的疾病活动性、新型化合物的有效性和安全性。从登记中获得的最大启示是我们目前对恶性肿瘤和感染风险的了解，同时也扩展了我们在临床试验中收集的关于比较效果、长期药物使用和代表性不足人群的知识。此外，还讨论了涉及大数据和人工智能的登记的可能演变，以及对以患者为中心的日益关注。
Role of rheumatoid arthritis registries worldwide: What have they taught us?
Rheumatoid arthritis (RA) is one of the most common rheumatic conditions, impacting quality of life on several domains. Major breakthroughs have been achieved over the past three decades in the management benefitting the patients' lives. With increasing as well as novel treatment options, clinical registries have been established and continuously evolve to portray patient characteristics, monitor disease activity of RA, effectiveness and safety of the novel compounds. The greatest insights derived from registries is our current knowledge on the risks for malignancies and infections but also extending our knowledge collected in clinical trials on comparative effectiveness, long-term drug utilisation and under-represented populations. Moreover, the possible evolution of registries involving Big Data and AI, and the increased focus on patient centredness is discussed.
期刊介绍：
Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions.
Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science.
The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update.
Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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