M Di Meglio, P Giunta, M Rechichi, A Trofa, G Galantuomo, N Galantuomo, S Palmieri, L Pacente, M Salducci
{"title":"用 0.01% 阿托品治疗儿童和青少年的渐进性近视:一项为期 4 年的意大利跟踪研究。","authors":"M Di Meglio, P Giunta, M Rechichi, A Trofa, G Galantuomo, N Galantuomo, S Palmieri, L Pacente, M Salducci","doi":"10.7417/CT.2024.5129","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effectiveness of atropine 0.01% in slowing the progression of myopia in young patients.</p><p><strong>Methods: </strong>2,387 patients with progressive myopia (more than -0.50 spherical diopters ‹D› increased in the last year) were enrolled. They received, every evening, one drop of atropine 0.01% in each eye. Refraction was then measured at baseline (T0) and once a year (T1, T2, T3, T4) for a 4-years follow-up period, and compared with a non-treated control group.</p><p><strong>Results: </strong>A reduction in the myopic progression was observed in the treated group respect to the control one. The average spherical refraction after 4 years increased by 27.06% in the treated group versus 241% of the control one. The difference in spherical increase between the two groups respect to time 0 was appreciable already at the first control, (T1 -T0, -0.21D vs. -1D) and continued to increase for all the 4-years follow-up period (T2-T0, -0.38D vs. -1.91D;T3-T0, -0.52D vs. -2.74D; T4-T0, -0.73D vs. -3.63D, respectively). It was always significant (P<0.01). Compared to the previous year, the average spherical increase was quite stable in the two groups (0.17 vs. 0.87, respectively). No significant tachyphylaxis or adverse effects were observed throughout the examination period.</p><p><strong>Conclusions: </strong>0.01% atropine was effective in slowing the progression of myopia in the treated group vs. control one. The clinical effect was noticeable already from the first control, and continued for all the observation period. The results of this study agree with those already reported in literature, and confirm the validity of this treatment.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"265-270"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Treatment of progressive myopia with 0.01% Atropine in children and adolescents: an Italian 4-year follow-up study.\",\"authors\":\"M Di Meglio, P Giunta, M Rechichi, A Trofa, G Galantuomo, N Galantuomo, S Palmieri, L Pacente, M Salducci\",\"doi\":\"10.7417/CT.2024.5129\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To assess the effectiveness of atropine 0.01% in slowing the progression of myopia in young patients.</p><p><strong>Methods: </strong>2,387 patients with progressive myopia (more than -0.50 spherical diopters ‹D› increased in the last year) were enrolled. They received, every evening, one drop of atropine 0.01% in each eye. Refraction was then measured at baseline (T0) and once a year (T1, T2, T3, T4) for a 4-years follow-up period, and compared with a non-treated control group.</p><p><strong>Results: </strong>A reduction in the myopic progression was observed in the treated group respect to the control one. The average spherical refraction after 4 years increased by 27.06% in the treated group versus 241% of the control one. The difference in spherical increase between the two groups respect to time 0 was appreciable already at the first control, (T1 -T0, -0.21D vs. -1D) and continued to increase for all the 4-years follow-up period (T2-T0, -0.38D vs. -1.91D;T3-T0, -0.52D vs. -2.74D; T4-T0, -0.73D vs. -3.63D, respectively). It was always significant (P<0.01). Compared to the previous year, the average spherical increase was quite stable in the two groups (0.17 vs. 0.87, respectively). 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引用次数: 0
摘要
目的:评估 0.01% 阿托品在延缓年轻患者近视度数加深方面的效果。方法:招募 2387 名渐进性近视患者(去年球面屈光度'D'增加-0.50 以上)。他们每天晚上在每只眼睛上滴一滴 0.01% 的阿托品。在为期 4 年的随访期间,分别在基线期(T0)和每年一次(T1、T2、T3、T4)测量屈光度,并与未接受治疗的对照组进行比较:结果:与对照组相比,治疗组的近视发展速度有所减缓。治疗组 4 年后的平均球面屈光度增加了 27.06%,而对照组增加了 241%。两组患者的球面屈光度与 0 时相比的增长差异在第一次对照时就已经很明显了(T1 -T0, -0.21D vs. -1D ),并在 4 年的随访期间持续增长(T2-T0, -0.38D vs. -1.91D; T3-T0, -0.52D vs. -2.74D; T4-T0, -0.73D vs. -3.63D)。该结果始终具有显著性(PConclusions:治疗组与对照组相比,0.01% 阿托品能有效减缓近视度数的加深。从第一次对照开始,临床效果就很明显,并持续了整个观察期。这项研究的结果与已有文献报道的结果一致,证实了这种治疗方法的有效性。
Treatment of progressive myopia with 0.01% Atropine in children and adolescents: an Italian 4-year follow-up study.
Purpose: To assess the effectiveness of atropine 0.01% in slowing the progression of myopia in young patients.
Methods: 2,387 patients with progressive myopia (more than -0.50 spherical diopters ‹D› increased in the last year) were enrolled. They received, every evening, one drop of atropine 0.01% in each eye. Refraction was then measured at baseline (T0) and once a year (T1, T2, T3, T4) for a 4-years follow-up period, and compared with a non-treated control group.
Results: A reduction in the myopic progression was observed in the treated group respect to the control one. The average spherical refraction after 4 years increased by 27.06% in the treated group versus 241% of the control one. The difference in spherical increase between the two groups respect to time 0 was appreciable already at the first control, (T1 -T0, -0.21D vs. -1D) and continued to increase for all the 4-years follow-up period (T2-T0, -0.38D vs. -1.91D;T3-T0, -0.52D vs. -2.74D; T4-T0, -0.73D vs. -3.63D, respectively). It was always significant (P<0.01). Compared to the previous year, the average spherical increase was quite stable in the two groups (0.17 vs. 0.87, respectively). No significant tachyphylaxis or adverse effects were observed throughout the examination period.
Conclusions: 0.01% atropine was effective in slowing the progression of myopia in the treated group vs. control one. The clinical effect was noticeable already from the first control, and continued for all the observation period. The results of this study agree with those already reported in literature, and confirm the validity of this treatment.
期刊介绍:
La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.