接触艾滋病毒与婴儿母体微嵌合 T 细胞组成的改变有关。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-02-20 DOI:10.1093/infdis/jiae521

Blair Armistead, M Quinn Peters, John Houck, Marc Carlson, Christina Balle, Nolawit Mulugeta, Clive M Gray, Heather B Jaspan, Whitney E Harrington

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引用次数: 0

摘要

暴露于艾滋病毒但未感染的婴儿（iHEU）的免疫力会发生改变，感染风险也会增加。我们以前曾报道过，iHEU 的母体微嵌合体（MMc）--在子宫内/母乳喂养期间转移给后代的母体细胞--减少了。我们对 iHEU 和未暴露婴儿（iHU）T 细胞亚群中的 MMc 进行了量化，以确定 MMc 的选择性缺乏是否会导致细胞免疫功能的改变。在所有婴儿中，CD8+ T 细胞中的 MMc 含量最高；但在 iHEU 中，CD8+ T 细胞 MMc 含量低于 iHU。在有限的功能研究中，我们没有发现婴儿原发性感染期间 CMV 特异性 MMc。

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Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.

Human immunodeficiency virus-exposed but uninfected infants (iHEU) display altered immunity and are at increased risk of infection. We previously reported that iHEU have decreased maternal microchimerism (MMc)-maternal cells transferred to the offspring in utero/during breastfeeding. We quantified MMc in T-cell subpopulations in iHEU and HIV-unexposed infants (iHU) to determine whether a selective deficiency in MMc contributes to altered cellular immunity. Across all infants, MMc levels were highest in CD8+ T cells; however, the level of CD8+ T-cell MMc was lower in iHEU versus iHU. In limited functional studies, we did not identify cytomegalovirus-specific MMc during infant primary infection.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.