"拉沙病毒诱发小鼠前庭功能障碍的病理学启示：内耳前庭装置的组织病理学分析"。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-04-15 DOI:10.1093/infdis/jiae516

Tomoharu Suzuki, Marina Hosotani Saito, Nantian Lin, Atsushi Tamura, Nadezhda Yun, Takaaki Koma, Junki Maruyama, Slobodan Paessler, Tomoko Makishima

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引用次数: 0

摘要

由拉沙病毒（LASV）感染引起的拉沙热（LF）通常会导致人类出现轻微症状，但一些幸存者会出现听觉前庭问题。在此，我们介绍了对拉沙热模型小鼠前庭组织病理学的深入研究。我们观察到1）前庭神经节和感觉上皮下基质内出血；2）毛细胞和支持细胞保存完好；3）前庭神经节细胞和感觉上皮下基质中存在 LASV 抗原；4）前庭神经节和感觉上皮下基质中存在 CD3 阳性 T 淋巴细胞浸润。LASV和/或其免疫反应可能是前庭功能障碍的发病机制之一。

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Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus.

Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.