早期生长应答 1 转录因子及其在胶质母细胞瘤中的环境依赖性功能。

IF 2.9 Q2 ONCOLOGY
Wspolczesna Onkologia-Contemporary Oncology Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI:10.5114/wo.2024.142583
Saleh Rasras, Esma'il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram
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引用次数: 0

摘要

胶质母细胞瘤是成人原发性脑肿瘤中最具侵袭性的一种。这种肿瘤利用许多转录因子来推动和维持其进展。目前的证据表明,早期生长应答 1(EGR1)在胶质母细胞瘤中扮演着致癌基因和肿瘤抑制因子的双重角色。早期生长反应 1 在胶质母细胞瘤中的表达非常普遍,影响到 80% 以上的病例。早期生长反应 1 的调控作用延伸到血管生成、细胞粘附和对化疗的耐受性,特别是对缺氧诱导因子 1α 和血管内皮生长因子 A 等通路的影响。早期生长反应 1 还能诱导胶质母细胞瘤细胞的细胞粘附、迁移、对替莫唑胺的化疗耐受性、干性和自我更新。尽管 EGR1 具有致癌功能,但它也能通过上调非甾体抗炎药物激活基因 1 和十号染色体上的磷酸酶和天丝蛋白同源物(phosphatase and tensin homolog deleted)抑制肿瘤,并抑制侵袭和转移。此外,EGR1 还可能对病毒 "打了就跑 "理论,特别是巨细胞病毒感染有假设性影响。本综述的主要发现是 EGR1 作用的环境依赖性及其作为胶质母细胞瘤预后标志物的潜力。要全面了解 EGR1 的作用并挖掘其在临床中的潜力,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early growth response 1 transcription factor and its context-dependent functions in glioblastoma.

Glioblastoma is the most aggressive form of primary brain tumour in adults. This tumour employs numerous transcription factors to advance and sustain its progression. Current evidence suggest that early growth response 1 (EGR1) plays a dual role as both an oncogene and a tumour suppressor in glioblastoma. Early growth response 1 expression is prevalent in glioblastoma, affecting over 80% of cases. Early growth response 1 regulatory roles extend to angiogenesis, cell adhesion, and resistance to chemotherapy, notably influencing pathways like hypoxia-inducible factor 1α and vascular endothelial growth factor A. Early growth response 1 can also induce cell adhesion, migration, chemoresistance against temozolomide, stemness, and self-renewal in glioblastoma cells. Despite its oncogenic functions, EGR1 can also suppress tumours by upregulating non-steroidal anti-inflammatory drug-activated gene 1 and phosphatase and tensin homolog deleted on chromosome ten, and inhibiting invasion and metastasis. Additionally, EGR1 may have hypothetical implications in the viral hit-and-run theory, particularly regarding cytomegalovirus infection. The key findings of this review are the context- dependent nature of EGR1's actions and its potential as a prognostic marker in glioblastoma. Further research is needed to understand EGR1's role fully and exploit its potential in clinics.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
22
审稿时长
4-8 weeks
期刊介绍: Contemporary Oncology is a journal aimed at oncologists, oncological surgeons, hematologists, radiologists, pathologists, radiotherapists, palliative care specialists, psychologists, nutritionists, and representatives of any other professions, whose interests are related to cancer. Manuscripts devoted to basic research in the field of oncology are also welcomed.
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