辅助生殖技术人群中年龄与流产之间的关系：一项为期 10 年的队列研究

IF 1.3 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI:10.18502/ijph.v53i9.16456

Doudou Zhao, Jie Chen, Xiayang Li, Zhaofang Li, Jingchen Zhang, Caixia Gao, Wenbo Hong, Danmeng Liu, Wenhao Shi, Juanzi Shi, Pengfei Qu

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引用次数: 0

摘要

背景：高龄产妇降低了辅助生殖技术（ART）治疗的成功怀孕率。我们的目的是调查需要进行 ART 受孕的妇女的年龄与流产之间的关系：方法：我们在中国西安进行了一项队列研究，对 10 年内 14,898 个接受 ART 治疗的妊娠周期进行了抽样调查。使用泊松回归模型评估了女性年龄对流产的影响。通过曲线拟合探讨了年龄与流产之间的临界效应：结果：与小于 30 岁的妇女相比，年龄越大的妇女发生早期流产和流产的风险越高（早期流产：[35-37 岁：]；流产：[35-37 岁：]）：[35-37岁：RR=1.48，95% 置信区间（CI）：1.26 至 1.74；≥38 岁：RR=2.25，95% 置信区间：1.87 至 2.72]；流产：[35-37岁：RR=1.45，95%CI：1.24 至 1.69；≥38 岁：RR=2.17，95%CI：1.82 至 2.60]）。观察到年龄与早期流产和流产之间存在非线性关系。在转折点（年龄=33 岁）之后，早期流产和流产的风险随着年龄的增长而迅速增加（结论：在接受抗逆转录病毒疗法的妊娠周期中，年龄越大，早期流产和流产的风险越高：在接受抗逆转录病毒疗法的妊娠周期中，高龄与较高的早期流产和流产风险相关，年龄与早期流产和流产之间存在非线性关系。应更加关注 33 岁以上孕妇接受 ART 治疗的风险。

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Association between Age and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study.

Background: Advanced maternal age decreased success of pregnancy rate in the assisted reproductive technology (ART) treatment. We aimed to investigate the association between age and miscarriages in women who required ART for conception.

Methods: A cohort study was conducted using a 10-year sample of 14,898 pregnancy cycles with ART treatment in Xi'an, China. The effects of women's age on miscarriage were assessed using Poisson regression models. The threshold effect between age and miscarriage was explored through curve fitting.

Results: Compared with lower than 30 years, the risks of early miscarriage and miscarriage were higher in the older age groups (early miscarriage: [35-37 years: RR=1.48, 95% confidence interval (CI): 1.26 to 1.74; ≥38 years: RR=2.25, 95% CI: 1.87 to 2.72]; miscarriage: [35-37 years: RR=1.45, 95%CI: 1.24 to 1.69; ≥38 years: RR=2.17, 95%CI: 1.82 to 2.60]). The nonlinear relationship between age and early miscarriage and miscarriages were observed. The risk of early miscarriage and miscarriage rapidly increased with age after the turning point (age=33 years) (<33 years: [early miscarriage: RR=1.02, 95% CI: 1.00 to 1.04; miscarriage: RR=1.02, 95% CI: 1.00 to 1.03]; ≥33 years: [early miscarriage: RR=1.11, 95% CI: 1.08 to 1.13; miscarriage: RR=1.10, 95% CI: 1.07 to 1.13]).

Conclusion: Among pregnancy cycles undergoing ART, advanced age is associated with higher risk of early miscarriage and miscarriage, and nonlinear relationship between age and early miscarriage and miscarriage were found. More attention should be paid to the risk of pregnant women with older than 33 years in ART treatment.

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来源期刊

Iranian Journal of Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

2.20

自引率

7.10%

发文量

300

审稿时长

3-8 weeks

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.