患有氯胺酮使用障碍的女性血浆瘦素水平较低,而男性则没有。

IF 2.7 3区 医学 Q2 PSYCHOLOGY, CLINICAL
Ming-Chyi Huang, Li-Jung Chiang, Wan-Hsi Chien, Tung-Hsia Liu, Chun-Hsin Chen, Yu-Li Liu
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引用次数: 0

摘要

背景:氯胺酮已成为一种常见的滥用药物。瘦素是一种源自脂肪细胞的多肽激素,与成瘾的形成有关。急性吸食氯胺酮后,瘦素水平的性别特异性变化已被证实;长期吸食氯胺酮对瘦素水平的持续影响尚不确定:与健康对照组相比,评估氯胺酮使用障碍(KUD)患者瘦素水平的性别差异及其持续性:方法:测量62名健康对照者(37名男性,25名女性)和68名氯胺酮使用障碍患者(50名男性,18名女性)在戒毒第一天(基线)以及戒毒1周和2周后的血浆瘦素水平。由于瘦素水平受体重指数(BMI)的影响,因此还研究了BMI调整瘦素(瘦素/BMI比值)。采用重复测量混合模型研究氯胺酮戒断后的变化:与同性对照组相比,女性氯胺酮患者在基线、第1周和第2周的瘦素水平和瘦素/体重指数比值较低(瘦素水平:分别为p = .001、0.006和0.032;瘦素/体重指数比值:分别为p = .004、0.022和0.09)。重复测量结果表明,KUD 男性参与者在禁欲 2 周后,瘦素水平和瘦素/体重指数比值均有所上升(p = .002 和 0.011,分别为 0.002 和 0.011),但女性参与者的瘦素水平和瘦素/体重指数比值没有上升(p > .05):结论:与对照组相比,KUD 患者的瘦素水平和瘦素/体重指数比率存在性别差异。KUD女性患者较低的瘦素水平在禁欲2周后仍持续存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma leptin levels are lower in females, but not males, with ketamine use disorder.

Background: Ketamine has emerged as a prominent substance of misuse. Leptin, an adipocyte-derived polypeptide hormone, has been implicated in the development of addiction. Sex-specific changes in leptin levels have been demonstrated following acute ketamine administration; the persistence of long-term ketamine use on leptin levels is uncertain.Objectives: To assess the sex-difference of leptin levels, and their persistence, in individuals with ketamine use disorder (KUD) compared to healthy controls.Methods: Plasma leptin levels were measured in 62 healthy controls (37 males, 25 females) and 68 participants with KUD (50 males, 18 females) on the first day (baseline) and after 1 and 2 weeks of abstinence. As leptin levels are affected by body mass index (BMI), BMI-adjusted leptin (leptin/BMI ratio) was also examined. Mixed model for repeated measures was used to examine changes after ketamine abstinence.Results: Compared to same-sex controls, female, but not male, participants with KUD demonstrated lower leptin levels and leptin/BMI ratio at baseline, week 1, and week 2 (leptin levels: p = .001, 0.006 and 0.032, respectively; leptin/BMI ratio: p = .004, 0.022, and 0.09, respectively). Repeated measures showed that leptin levels and the leptin/BMI ratio increased after 2 weeks of abstinence in male participants with KUD (p = .002 and 0.011, respectively), but females did not show such an increase (p > .05).Conclusions: Sex-specific differences were observed in leptin levels and the leptin/BMI ratio in individuals with KUD compared to controls. Lower leptin levels in females with KUD persisted after 2 weeks of abstinence.

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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
68
期刊介绍: The American Journal of Drug and Alcohol Abuse (AJDAA) is an international journal published six times per year and provides an important and stimulating venue for the exchange of ideas between the researchers working in diverse areas, including public policy, epidemiology, neurobiology, and the treatment of addictive disorders. AJDAA includes a wide range of translational research, covering preclinical and clinical aspects of the field. AJDAA covers these topics with focused data presentations and authoritative reviews of timely developments in our field. Manuscripts exploring addictions other than substance use disorders are encouraged. Reviews and Perspectives of emerging fields are given priority consideration. Areas of particular interest include: public health policy; novel research methodologies; human and animal pharmacology; human translational studies, including neuroimaging; pharmacological and behavioral treatments; new modalities of care; molecular and family genetic studies; medicinal use of substances traditionally considered substances of abuse.
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