Carlos Ochoa-Leite, Sara Rodrigues, Ana Sofia Ramos, Flávio Ribeiro, João Barbosa, Carmen Jerónimo, Paula Guedes de Pinho, Ricardo Jorge Dinis-Oliveira, José Torres Costa
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The use of 'omics' technologies, such as metabolomics and proteomics, has become crucial in detecting subtle biological alterations induced by occupational hazards, thereby opening novel avenues for biomarker discovery.</p><p><strong>Aims: </strong>This systematic review aims to evaluate the application of metabolomics and proteomics in occupational health.</p><p><strong>Methods: </strong>Following the PRISMA guidelines, we conducted a comprehensive search on PubMed, Scopus, and Web of Science for original human studies that use metabolomics or proteomics to assess occupational exposure biomarkers. The risk of bias was assessed by adapting the Cochrane Collaboration tool and the Newcastle-Ottawa Quality Assessment Scale.</p><p><strong>Results: </strong>Of 2311 initially identified articles, 85 met the eligibility criteria. These studies were mainly conducted in China, Europe, and the United States of America, covering a wide range of occupational exposures. 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引用次数: 0
摘要
背景：职业生物监测对于评估与工作场所接触有关的健康风险至关重要。目的：本系统综述旨在评估代谢组学和蛋白质组学在职业健康中的应用：按照 PRISMA 指南，我们在 PubMed、Scopus 和 Web of Science 上对使用代谢组学或蛋白质组学评估职业暴露生物标志物的原始人类研究进行了全面搜索。采用 Cochrane 协作工具和纽卡斯尔-渥太华质量评估量表对偏倚风险进行了评估：在初步确定的 2311 篇文章中，有 85 篇符合资格标准。这些研究主要在中国、欧洲和美国进行，涉及多种职业暴露。研究结果表明，代谢组学和蛋白质组学方法有效地确定了与化学、物理、生物力学和社会心理危害相关的生物标志物。分析方法多种多样，其中以质谱技术最为普遍。出现偏差的风险一般为低到中度，特别关注暴露测量和混杂因素：结论：将代谢组学和蛋白质组学整合到职业健康生物监测中，能极大地促进我们对暴露影响的了解，并有助于制定个性化的预防干预措施。然而，数据分析的复杂性、生物标志物的特异性以及将研究结果转化为预防措施等方面仍然存在挑战。未来的研究应侧重于纵向研究和不同人群的生物标志物验证，以提高职业健康干预措施的可靠性和适用性。
Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.
Background: Occupational biomonitoring is essential for assessing health risks linked to workplace exposures. The use of 'omics' technologies, such as metabolomics and proteomics, has become crucial in detecting subtle biological alterations induced by occupational hazards, thereby opening novel avenues for biomarker discovery.
Aims: This systematic review aims to evaluate the application of metabolomics and proteomics in occupational health.
Methods: Following the PRISMA guidelines, we conducted a comprehensive search on PubMed, Scopus, and Web of Science for original human studies that use metabolomics or proteomics to assess occupational exposure biomarkers. The risk of bias was assessed by adapting the Cochrane Collaboration tool and the Newcastle-Ottawa Quality Assessment Scale.
Results: Of 2311 initially identified articles, 85 met the eligibility criteria. These studies were mainly conducted in China, Europe, and the United States of America, covering a wide range of occupational exposures. The findings revealed that metabolomics and proteomics approaches effectively identified biomarkers related to chemical, physical, biomechanical, and psychosocial hazards. Analytical methods varied, with mass spectrometry-based techniques emerging as the most prevalent. The risk of bias was generally low to moderate, with specific concerns about exposure measurement and confounding factors.
Conclusions: Integrating metabolomics and proteomics in occupational health biomonitoring significantly advances our understanding of exposure effects and facilitates the development of personalized preventive interventions. However, challenges remain regarding the complexity of data analysis, biomarker specificity, and the translation of findings into preventive measures. Future research should focus on longitudinal studies and biomarker validation across diverse populations to improve the reliability and applicability of occupational health interventions.
期刊介绍：
Aimed at clinicians and researchers, the Journal of Occupational Medicine and Toxicology is a multi-disciplinary, open access journal which publishes original research on the clinical and scientific aspects of occupational and environmental health.
With high-quality peer review and quick decision times, we welcome submissions on the diagnosis, prevention, management, and scientific analysis of occupational diseases, injuries, and disability. The journal also covers the promotion of health of workers, their families, and communities, and ranges from rehabilitation to tropical medicine and public health aspects.
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