免疫代谢重新布线:宏量营养素与巨噬细胞的故事

Q4 Biochemistry, Genetics and Molecular Biology
Gerasimos Anagnostopoulos, Camille Blériot, Nicolas Venteclef, Florent Ginhoux
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引用次数: 0

摘要

髓系细胞,包括单核细胞、巨噬细胞、树突状细胞和多形核细胞,是维持体内平衡和免疫反应的关键组成部分。在髓系细胞中,巨噬细胞是一种用途广泛的细胞,不仅能保护组织功能,还能感知潜在的有害微环境线索并做出反应。大量研究表明,营养状况和宏量营养素的可用性会影响巨噬细胞的特性和功能。然而,人们才刚刚开始了解宏量营养素摄入与细胞代谢变化之间的确切机理联系。在本章中,我们将探讨膳食中的 "宏量营养素"--碳水化合物、脂肪和氨基酸--如何影响巨噬细胞在健康和炎症组织中的免疫调节活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages.

Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.

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来源期刊
Results and Problems in Cell Differentiation
Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
1.90
自引率
0.00%
发文量
21
期刊介绍: Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.
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