Stuart Knechtle, Annette Jackson, Joseph Ladowski, Jean Kwun, Massimo Mangiola, A Joseph Tector, Léo H Bühler, Emanuele Cozzi, David K C Cooper
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引用次数: 0
摘要
本报告总结了由 eGenesis Bio 赞助、国际异种移植协会 (IXA) 组织的一场辩论的内容,150 多名代表参加了 2023 年 10 月在圣地亚哥举行的 IPITA-IXA-CTRMS 联合大会。辩论围绕与异种移植相关的两个重要免疫学话题展开。首先是关于 "HLA致敏患者排斥猪异种移植的风险更高 "这一说法的辩论。Stuart Knechtle 提供了支持这一说法的证据,而 Massimo Mangiola 则表示反对。辩论前,大多数(>80%)听众同意这一说法。听完辩论后,这一比例降至约 60%。第二个辩题是 "猪异种移植物的受体如果产生抗猪抗体,那么随后的同种异体移植物发生排斥反应的风险更高"。这是由 A. Joseph Tector 提出的,遭到了 Léo H. Bühler 的反对。在辩论之前,大多数听众(约 60%)再次认为,事先对猪异种移植物过敏会不利于随后异种移植物的存活。然而,在听完辩论后,只有约 40% 的人认为这种说法是正确的。讨论的话题依然复杂,答案尚无定论。不过,目前的证据表明,异体致敏可能对随后的异种移植不利,而对猪抗原致敏则可能对随后的同种异体移植无害。
Is Allosensitization Detrimental to Pig Organ Xenotransplantation, and Is Xenosensitization Detrimental to Subsequent Organ Allotransplantation? A Debate Organized by the International Xenotransplantation Association (IXA).
This report summarizes the content of a debate sponsored by eGenesis Bio, organized by the International Xenotransplantation Association (IXA), and attended by more than 150 delegates in the context of the IPITA-IXA-CTRMS Joint Congress held in San Diego in October 2023. The debate centered around two important immunological topics relating to xenotransplantation. The first was a debate relating to the statement that "HLA-sensitized patients are at higher risk for rejecting a pig xenograft." Stuart Knechtle provided evidence to support this statement and Massimo Mangiola opposed it. Before the debate, a majority (>80%) of the audience agreed with this statement. After listening to the debate, this percentage was reduced to approximately 60%. The second debated statement was "Recipients of pig xenografts who develop anti-pig antibodies are at higher risk for rejecting a subsequent allograft." This was proposed by A. Joseph Tector and opposed by Léo H. Bühler. Before the debate, once again a majority of the audience (approximately 60%) believed that prior sensitization to a pig xenograft would be detrimental to the survival of a subsequent allograft. However, after listening to the debate, only about 40% believed this statement to be correct. The topics discussed remain complex and answers are not yet conclusive. However, the present evidence suggests that allosensitization may prove detrimental to subsequent xenotransplantation, whilst sensitization to pig antigens may not be detrimental to subsequent allotransplantation.
期刊介绍:
Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.