同型半胱氨酸与城市成年人抑郁和焦虑症状的纵向联系:跨寿命多样性社区健康老龄化研究。

IF 5.8 1区 医学 Q1 PSYCHIATRY
Michael F Georgescu, May A Beydoun, Christian A Maino Vieytes, Marie T Fanelli-Kuczmarski, Jason Ashe, Hind A Beydoun, Sharmin Hossain, Nicole Noren Hooten, Michele K Evans, Alan B Zonderman
{"title":"同型半胱氨酸与城市成年人抑郁和焦虑症状的纵向联系:跨寿命多样性社区健康老龄化研究。","authors":"Michael F Georgescu, May A Beydoun, Christian A Maino Vieytes, Marie T Fanelli-Kuczmarski, Jason Ashe, Hind A Beydoun, Sharmin Hossain, Nicole Noren Hooten, Michele K Evans, Alan B Zonderman","doi":"10.1038/s41398-024-03111-7","DOIUrl":null,"url":null,"abstract":"<p><p>Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30-64 y at v<sub>1</sub> (2004-2009), followed across 3 visits up to 2017. In addition to LnHcy<sub>v1</sub>, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcy<sub>traj</sub>). Total and domain-specific depression symptoms were scored using Center for Epidemiologic Studies Depression (CES-D) scale. Mixed-effects linear regression models and Cox proportional hazards models were utilized. A positive association was found between baseline LnHcy<sub>v1</sub> and CES-D total scores in reduced socio-demographic- adjusted Model 1 (β (standard error [SE]) = + 2.337 (0.902), P = 0.010), a relationship slightly attenuated in fully adjusted Model 2 (Model 1 adjusting for lifestyle and health factors) with a β (SE) = + 1.825 (0.883), P = 0.039. Individuals with lower anxiety levels experienced faster CES-D domain 2 score annualized increase over time (interpersonal problems) with higher LnHcy<sub>v1</sub> (β (SE) = 0.041 (0.018), P = 0.024). Hcy<sub>traj</sub> was linked to incident elevated depressive symptoms (CES-D total score ≥16) overall (fully adjusted model: HR = 1.09, 95% CI: 1.03-1.14, P = 0.001), particularly among women and those living in poverty. Baseline and \"high trajectory\" of LnHcy were positively associated with depressive symptoms and elevated depressive symptom incidence, in a sex-, race-, poverty status- and anxiety-level specific manner.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490487/pdf/","citationCount":"0","resultStr":"{\"title\":\"Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.\",\"authors\":\"Michael F Georgescu, May A Beydoun, Christian A Maino Vieytes, Marie T Fanelli-Kuczmarski, Jason Ashe, Hind A Beydoun, Sharmin Hossain, Nicole Noren Hooten, Michele K Evans, Alan B Zonderman\",\"doi\":\"10.1038/s41398-024-03111-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30-64 y at v<sub>1</sub> (2004-2009), followed across 3 visits up to 2017. In addition to LnHcy<sub>v1</sub>, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcy<sub>traj</sub>). Total and domain-specific depression symptoms were scored using Center for Epidemiologic Studies Depression (CES-D) scale. Mixed-effects linear regression models and Cox proportional hazards models were utilized. A positive association was found between baseline LnHcy<sub>v1</sub> and CES-D total scores in reduced socio-demographic- adjusted Model 1 (β (standard error [SE]) = + 2.337 (0.902), P = 0.010), a relationship slightly attenuated in fully adjusted Model 2 (Model 1 adjusting for lifestyle and health factors) with a β (SE) = + 1.825 (0.883), P = 0.039. Individuals with lower anxiety levels experienced faster CES-D domain 2 score annualized increase over time (interpersonal problems) with higher LnHcy<sub>v1</sub> (β (SE) = 0.041 (0.018), P = 0.024). Hcy<sub>traj</sub> was linked to incident elevated depressive symptoms (CES-D total score ≥16) overall (fully adjusted model: HR = 1.09, 95% CI: 1.03-1.14, P = 0.001), particularly among women and those living in poverty. Baseline and \\\"high trajectory\\\" of LnHcy were positively associated with depressive symptoms and elevated depressive symptom incidence, in a sex-, race-, poverty status- and anxiety-level specific manner.</p>\",\"PeriodicalId\":23278,\"journal\":{\"name\":\"Translational Psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2024-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490487/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41398-024-03111-7\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41398-024-03111-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

摘要

对于同型半胱氨酸(HCY)与城市成年人抑郁症状得分之间的纵向关系,尤其是不同性别、种族和焦虑程度的同型半胱氨酸与抑郁症状得分之间的纵向关系的研究仍然不足。我们研究了城市成年人中同型半胱氨酸(HCY)与抑郁症状评分的纵向关系,在按性别、种族和焦虑程度分层之前和之后,我们使用了 1460 名年龄在 30-64 岁的 "跨生命周期多样性社区健康老龄化研究"(Healthy Aging in Neighborhoods of Diversity across the Lifespan Study,HANDLS)参与者的数据,这些参与者的年龄在 v1 阶段(2004-2009 年)为 30-64 岁,我们对他们进行了 3 次随访,直至 2017 年。除了 LnHcyv1 之外,我们还使用了基于群体的轨迹模型来预测随着年龄增长 LnHcy 变大的 z 变形可能性(Hcytraj)。采用流行病学研究中心抑郁(CES-D)量表对总的和特定领域的抑郁症状进行评分。研究采用了混合效应线性回归模型和 Cox 比例危险模型。在降低社会-人口因素调整后的模型 1 中(β(标准误差 [SE])= + 2.337 (0.902),P = 0.010),基线 LnHcyv1 与 CES-D 总分之间存在正相关,在完全调整后的模型 2(模型 1 调整了生活方式和健康因素)中,这种关系略有减弱,β(标准误差)= + 1.825 (0.883),P = 0.039。焦虑水平较低的个体随着时间的推移,CES-D 领域 2 分数(人际关系问题)的年增长率较快,LnHcyv1 较高(β (SE) = 0.041 (0.018),P = 0.024)。总体而言,Hcytraj 与抑郁症状升高(CES-D 总分≥16)有关(完全调整模型:HR = 1.09,95% CI:1.03-1.14,P = 0.001),尤其是在女性和贫困人群中。LnHcy的基线和 "高轨迹 "与抑郁症状和抑郁症状发生率的升高呈正相关,具体方式与性别、种族、贫困状况和焦虑程度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.

Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30-64 y at v1 (2004-2009), followed across 3 visits up to 2017. In addition to LnHcyv1, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcytraj). Total and domain-specific depression symptoms were scored using Center for Epidemiologic Studies Depression (CES-D) scale. Mixed-effects linear regression models and Cox proportional hazards models were utilized. A positive association was found between baseline LnHcyv1 and CES-D total scores in reduced socio-demographic- adjusted Model 1 (β (standard error [SE]) = + 2.337 (0.902), P = 0.010), a relationship slightly attenuated in fully adjusted Model 2 (Model 1 adjusting for lifestyle and health factors) with a β (SE) = + 1.825 (0.883), P = 0.039. Individuals with lower anxiety levels experienced faster CES-D domain 2 score annualized increase over time (interpersonal problems) with higher LnHcyv1 (β (SE) = 0.041 (0.018), P = 0.024). Hcytraj was linked to incident elevated depressive symptoms (CES-D total score ≥16) overall (fully adjusted model: HR = 1.09, 95% CI: 1.03-1.14, P = 0.001), particularly among women and those living in poverty. Baseline and "high trajectory" of LnHcy were positively associated with depressive symptoms and elevated depressive symptom incidence, in a sex-, race-, poverty status- and anxiety-level specific manner.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信