益生菌作为佐剂,可减轻食物过敏免疫疗法的不良反应并提高疗效。

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Scandinavian Journal of Immunology Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI:10.1111/sji.13405
Ingrid Lamminpää, Elena Niccolai, Amedeo Amedei
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引用次数: 0

摘要

在过去的几十年里,食物过敏在儿童早期就已日益普遍,导致生活质量下降,医疗保健系统的费用不断增加。除了标准的避免接触特定过敏原和接触过敏原后的药物治疗外,大量研究最近集中在食物过敏原免疫疗法(FA-AIT)上。SCIT和EPIT(皮下和表皮免疫疗法)、OIT(口服免疫疗法)和SLIT(舌下免疫疗法)都是通过逐渐接触过敏原来脱敏,并在治疗结束后达到耐受。FA-AIT虽然前景广阔,但可能会带来急性局部和全身不良反应。为了提高口服免疫疗法的疗效、安全性和便利性,寻找潜在的佐剂来减轻不良反应变得至关重要。在特定益生菌菌株中观察到了免疫调节活性,如增加调节性 T 细胞和降低 IgE,多项研究阐明了肠道微生物群在宿主及其免疫系统中的重要作用。在这篇综述中,微生物组调节被认为是潜在的 AIT 佐剂,然而在不久的将来,需要更多的临床研究来评估靶向细菌疗法和粪便微生物组移植的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Probiotics as adjuvants to mitigate adverse reactions and enhance effectiveness in Food Allergy Immunotherapy.

In the past decades, food allergies became increasingly dominant since early childhood, leading to a lower quality of life and to increasing costs addressed by the health care system. Beside standard avoidance of specific allergens and drug treatments following allergen exposure, a great deal of research has lately focused on Food Allergy Allergen Immunotherapy (FA-AIT). SCIT and EPIT (Subcutaneous and Epicutaneous Immunotherapy), OIT (Oral Immunotherapy), and SLIT (Sublingual Immunotherapy) consist in gradual exposure to allergens to desensitize and achieve tolerance once therapy has ended. Although promising, FA-AIT may bring acute local and systemic adverse reactions. To enhance efficacy, safety and convenience of AIT, the quest of potential adjuvants to mitigate the adverse reactions becomes crucial. Immunomodulatory activities, such as that of increasing the regulatory T cells and decreasing the IgE, have been observed in specific probiotics' strains and multiple studies elucidated the role of gut microbiota as a major interplayer among the host and its immune system. In this review, the microbiome modulation is shown as potential AIT adjuvant, nevertheless the need of more clinical studies in the near future is pivotal to assess the efficacy of targeted bacterial therapies and faecal microbiota transplantation.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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