炎症性肠病发病机制中的 T 细胞反应失调。

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Scandinavian Journal of Immunology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI:10.1111/sji.13412
Rucha Chandwaskar, Rajdeep Dalal, Saurabh Gupta, Aishwarya Sharma, Deepak Parashar, Vivek K Kashyap, Jagdip Singh Sohal, Subhash K Tripathi
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引用次数: 0

摘要

炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),是一种肠道炎症性疾病,早先在西半球流行,但现在在东方呈上升趋势,印度的发病率位居世界第二。IBD 中的炎症是免疫反应失调的一个原因,其中辅助性 T(Th)细胞亚群及其细胞因子在 IBD 的发病机制中起着重要作用。此外,肠道微生物群、环境因素(如饮食因素)和宿主遗传也会影响 IBD 的结果和严重程度。效应T细胞和调节T细胞之间的失调是肠道炎症的诱因,因为在IBD患者中,Th1、Th17和Th9亚群Th细胞系等效应T细胞增多。在这篇综述中,我们试图讨论不同 Th 细胞亚群与其他 T 细胞(如 CD8+ T 细胞、NKT 和 γδT 细胞)在 IBD 肠道炎症中的作用。我们还强调了 IBD 的潜在候选疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease.

Inflammatory bowel disease (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are gut inflammatory diseases that were earlier prevalent in the Western Hemisphere but now are on the rise in the East, with India standing second highest in the incidence rate in the world. Inflammation in IBD is a cause of dysregulated immune response, wherein helper T (Th) cell subsets and their cytokines play a major role in the pathogenesis of IBD. In addition, gut microbiota, environmental factors such as dietary factors and host genetics influence the outcome and severity of IBD. Dysregulation between effector and regulatory T cells drives gut inflammation, as effector T cells like Th1, Th17 and Th9 subsets Th cell lineages were found to be increased in IBD patients. In this review, we attempted to discuss the role of different Th cell subsets together with other T cells like CD8+ T cells, NKT and γδT cells in the outcome of gut inflammation in IBD. We also highlighted the potential therapeutic candidates for IBD.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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