茎皮中的化学成分及其抗炎活性。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-10-16 DOI:10.1016/j.phytochem.2024.114302

Chuntong Li , Deduo Xu , Zhancai Zheng , Wenquan Lu , Yingbo Yang , Wansheng Chen , Zhijun Wu

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引用次数: 0

摘要

从 Illicium burmanicum 的茎皮提取物中分离出了 36 种化合物，包括 12 种以前未曾描述过的前烯化 C6-C3 化合物和一种后半萜内酯：伊利西酮 D (1)、伊利西酮 E (2)、伊利西酮 F (3)、伊利西酮 G (4)、(2R,4S,11R)-12-O-乙基illifunone C (5)、(2R,4S,11R)-illifunone C-12-O-β-d-glucopyranoside (6)、(2R,4S、11R)-2-hydroxyillifunone C (7)、4-epi-2,3-dehydroillifunone C (8)、illiburmanone A (9)、illiburmanone B (10)、illiburmanlactone A (11)、(2S,4S,5S,11R)-2,3-dihydroillicione E (12) 和 illiburmanolside A (13)。它们的结构是根据大量的光谱数据分析（包括 MS、NMR 和 ECD 光谱）确定的。对分离出的化合物（1-36）的抗炎活性进行了评估，化合物 7、12、14 和 18 对 LPS 诱导的 RAW 264.7 细胞有抑制作用。

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Chemical constituents from the stem bark of Illicium burmanicum and their anti-inflammatory activity

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Chemical constituents from the stem bark of Illicium burmanicum and their anti-inflammatory activity

Thirty-six compounds were isolated from extract of the stem bark of Illicium burmanicum, including twelve previously undescribed prenylated C6–C3 compounds and a norsesquiterpene lactone: illicidione D (1), illicidione E (2), illicidione F (3), illicidione G (4), (2R,4S,11R)-12-O-ethylillifunone C (5), (2R,4S,11R)-illifunone C-12-O-β-d-glucopyranoside (6), (2R,4S,11R)-2-hydroxyillifunone C (7), 4-epi-2,3-dehydroillifunone C (8), illiburmanone A (9), illiburmanone B (10), illiburmanlactone A (11), (2S,4S,5S,11R)-2,3-dihydroillicione E (12), and illiburmanolside A (13). Their structures were determined based on extensive spectroscopic data analyses, including MS, NMR, and ECD spectra. The anti-inflammatory activity of the isolated compounds (1–36) was evaluated, and compounds 7, 12, 14, and 18 exhibited inhibitory effects in RAW 264.7 cells induced by LPS.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.