从昆虫物种 Aspongopus chinensis 中提取的氨基酸衍生吡啶鎓盐 Aspongpyridiniums A-J。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-10-15 DOI:10.1016/j.phytochem.2024.114299

Jinchun Nie, Shuang Guo, Didi Wang, Zhenwei Li, Daidi Zhang, Wei Li, De-An Guo

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引用次数: 0

摘要

从昆虫物种 Aspongopus chinensis 的 50%MeOH提取物的正-BuOH馏分中分离并鉴定了 Aspongpyridiniums A-J（1-10），这十种氨基酸衍生的吡啶鎓盐之前从未被描述过。通过大量光谱数据以及电子圆二色性计算和比较，确定了它们的结构。Aspongpyridiniums A-J 的结构特征是独特的 1,3,4-三取代吡啶鎓骨架和一个来自氨基酸单元的可变官能团。在生物测定中，化合物 5 和 10 对α-葡萄糖苷酶具有一定的抑制活性，而 1-10 则对乙酰胆碱酯酶具有中度到微弱的抑制作用。

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Aspongpyridiniums A-J, amino acid-derived pyridinium salts from insect species Aspongopus chinensis.

Aspongpyridiniums A-J (1-10), ten previously undescribed amino acid-derived pyridinium salts were isolated and identified from the n-BuOH fraction of the 50% MeOH extract of insect species Aspongopus chinensis, well-known for its use in traditional Chinese medicine for the treatment of pain, indigestion and kidney diseases. Their structures were determined by extensive spectroscopic data as well as electronic circular dichroism calculations and comparisons. Aspongpyridiniums A-J are structurally characterized by a unique 1,3,4-trisubstituted pyridinium skeleton with a variable functional group derived from an amino acid unit. In bioassays, Compounds 5 and 10 exhibited certain inhibitory activities against α-glucosidase, while 1-10 showed moderate to weak acetylcholinesterase inhibitory effects.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.