丁苯酞治疗颅内动脉狭窄引起的中风患者的疗效。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Xudong Lu, Shuxia Qian, Yanping Wang, Xiaoling Zhang, Yuhua Jin, Bo Yu
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引用次数: 0

摘要

目的:探讨丁苯酞治疗颅内动脉狭窄(ICAS)所致中风患者的临床疗效:探讨丁苯酞治疗颅内动脉狭窄(ICAS)所致脑卒中患者的临床疗效:回顾性分析 2021 年 1 月至 2023 年 1 月嘉兴市第二医院收治的 163 例 ICAS 脑卒中患者的病历。根据患者接受治疗的情况分为两组:对照组(患者接受常规治疗,人数=55)和观察组(患者接受丁苯酞常规治疗,人数=58)。比较两组患者治疗前后脑血管反应性(CVR)、屏气指数(BHI)、搏动指数(PI)和大脑中动脉平均流速(Vm)水平的变化。此外,还比较了两组患者治疗前后的认知功能、神经功能和生活能力,以及治疗的总体临床疗效:结果:两组的基线数据具有可比性(P>0.05)。治疗后,观察组的CVR、BHI、Vm指标明显高于对照组,而PI指标水平明显低于对照组(PPConclusions:在常规治疗的基础上加用丁苯酞,可有效改善脑血管储备功能,促进神经和认知功能障碍的恢复,提高ICAS所致脑卒中患者的日常生活能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of butylphthalide in the treatment of patients with stroke attributed to intracranial arterial stenosis.

Objective: To explore the clinical efficacy of butylphthalide in treating patients with stroke attributed to intracranial artery stenosis (ICAS).

Methods: In this retrospective study, records of 163 patients with stroke attributed to ICAS admitted to Jiaxing Second Hospital from January 2021 to January 2023 were retrospectively analyzed. Patients were divided into two groups based on the treatment received: control group (patients received routine treatment, n=55) and observation group (patients treated with butylphthalide on a routine basis, n=58). Changes in levels of cerebrovascular reactivity (CVR), breath-holding index (BHI), pulsatility index (PI), and middle cerebral artery mean flow velocity (Vm) between the two groups before and after treatment were compared. In addition, cognitive function, neurological function, and living ability were compared between the two groups before and after treatment, as well as the overall clinical efficacy of the treatment.

Results: The baseline data was comparable between the two groups (P>0.05). After the treatment, CVR, BHI, and Vm indicators in the observation group were significantly higher than those in the control group, while the levels of PI indexes were significantly lower than those in the control group (P<0.05). Montreal Cognitive Assessment (MoCA) and Barthel scale scores of the observation group were significantly higher compared to the control group, while the scores of National Institutes of Health Stroke Scale (NIHSS) were significantly lower (P<0.05).

Conclusions: Butylphthalide in addition to routine treatment can effectively improve cerebrovascular reserve function, promote neurological and cognitive dysfunction recovery, and enhance daily living ability of patients with stroke caused by ICAS.

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来源期刊
Pakistan Journal of Medical Sciences
Pakistan Journal of Medical Sciences 医学-医学:内科
CiteScore
4.10
自引率
9.10%
发文量
363
审稿时长
3-6 weeks
期刊介绍: It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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