右美托咪定可改善手术应激反应。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Khalida Ajmal, Akbar Waheed, Rashada Farooqi, Qaisar Mansoor
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引用次数: 0

摘要

目的确定围手术期静脉注射右美托咪定(Dex)对耳鼻喉科手术患者应激反应指标的影响:这项随机干预研究于 2021 年 10 月至 2022 年 4 月在巴基斯坦华坎特的 POFs 医院和 NUMS 附属 WMC 与 IIMC Rawalpindi 合作开展。符合纳入标准的 100 名 15-60 岁患者被随机分为 C 组和 D 组。干预组-D(50 人)在诱导前 10 分钟静脉注射 1µg/kg 盐酸右美托咪定,然后以 0.5µg/kg/hr 的剂量维持至手术结束。两组患者的血清炎症生物标志物(白细胞介素-6、TNF-α和皮质醇)分别在0分钟(T0)、30分钟(T1)和两小时(T2)时采集,并通过酶联免疫吸附试验(ELISA)进行分析。数据使用 SPSS 23 进行统计分析:接受地塞米松治疗的患者血清皮质醇、TNF- α和白细胞介素-6水平明显下降,分别从139.73降至10.18、99.51降至0.96和85.09降至0.96。C组和D组之间的比较显示,这些血清生物标志物存在显著差异(P≤0.05):在本研究中,静脉注射 Dex 可抑制术中细胞因子分泌水平的升高,促进术后顺利恢复,且无恶心和呕吐发生。这些作用可归因于右美托咪定的抗炎作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dexmedetomidine leads to the amelioration of stress response to surgery.

Objectives: To determine the impact of intravenous Dexmedetomidine (Dex) administered perioperatively on stress response markers in patients undergoing ENT surgeries.

Methods: This randomized interventional study was conducted at POFs Hospital and NUMS affiliated WMC, Wah Cantt, in collaboration with IIMC Rawalpindi, Pakistan, from October 2021 to April 2022. One hundred patients aged between 15-60 years, after satisfying the inclusion standards were randomly divided into two groups C and D. Group-C (n=50) received normal saline in addition to the standard anesthesia protocol. The intervention Group-D (n=50) was administered 1µg/kg dexmedetomidine hydrochloride intravenously over 10 minutes just before the induction followed 0.5μg/kg/hr as maintenance dose till the end of surgery. Serum inflammatory biomarkers (interleukins-6, TNF-α and cortisol) were measured in blood samples in both groups, taken at 0 (T0), 30 minutes(T1), and two hours (T2) time intervals and analyzed by using Enzyme-linked immunosorbent assay (ELISA). Data was statistically analyzed using SPSS 23.

Results: The patients receiving Dex showed marked decrease in serum levels of cortisol, TNF- α and interleukins-6, from 139.73 to10.18, 99.51 to 0.96 and 85.09 to 0.96 respectively. Comparison between C and D groups revealed significant differences (p≤0.05) in these serum biomarkers.

Conclusions: In the present study, intravenous Dex suppressed the intraoperative rise in levels of cytokine secretion and enhanced smooth recovery with no incidence of nausea and vomiting. These effects could be attributed to the anti-inflammatory effects of dexmedetomidine.

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来源期刊
Pakistan Journal of Medical Sciences
Pakistan Journal of Medical Sciences 医学-医学:内科
CiteScore
4.10
自引率
9.10%
发文量
363
审稿时长
3-6 weeks
期刊介绍: It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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