男性不育症的药物疗法。

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Amarnath Rambhatla, Rupin Shah, Germar M Pinggera, Taymour Mostafa, Widi Atmoko, Ramadan Saleh, Eric Chung, Taha Hamoda, Selahittin Cayan, Hyun Jun Park, Ates Kadioglu, Logan Hubbard, Ashok Agarwal
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引用次数: 0

摘要

男性因素不育是一个多方面的问题,影响着约 50%的不育夫妇。导致男性不育的原因包括内分泌紊乱、性腺毒素、遗传异常、精索静脉曲张、恶性肿瘤、感染、先天性或后天性泌尿生殖系统异常、先天性因素、免疫因素和特发性原因。男性不育有多种治疗方案,具体取决于潜在的病因。其中包括手术治疗、药物/激素疗法和辅助生殖技术(ART),必要时可结合手术取精(SSR)。在这篇综述文章中,男性不育症的药物疗法按其根本原因进行了分类。其中一些疗法具有针对性和特异性,而另一些则是根据经验用于治疗特发性男性不育症。这将包括优化性腺功能减退症、射精功能障碍、感染或特发性男性不育患者不育症的治疗方法。最后,我们将概述男性不育症药物疗法的未来发展方向。意义声明 男性不育是一个严重的世界性问题。对现有药物疗法的详细了解将确保开出适当的治疗处方,避免使用不必要或有害的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological therapies for male infertility.

Male factor infertility is a multifaceted problem that affects approximately 50% of couples suffering from infertility. Causes of male infertility include endocrine disturbances, gonadotoxins, genetic abnormalities, varicocele, malignancies, infections, congenital or acquired urogenital abnormalities, iatrogenic factors, immunological factors, and idiopathic reasons. There are a variety of treatment options for male infertility, depending on the underlying cause(s). These can include surgical treatments, medical/hormonal therapies, and assisted reproductive techniques (ART), which can be combined with surgical sperm retrieval (SSR) if necessary. In this review article, the pharmacological therapies for male infertility are grouped by their underlying causes. Some of these therapies are targeted and specific, while others are used empirically to treat idiopathic male infertility. This will include treatments to optimize infertility in patients who have hypogonadism, ejaculatory dysfunction, infections, or idiopathic male infertility. Finally, we will provide an overview of the future directions of pharmacological therapies for male infertility. Significance Statement Male infertility is a significant worldwide problem. Detailed knowledge of the pharmacological therapies available will ensure the prescription of appropriate therapy and avoid the use of unnecessary or harmful treatments.

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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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