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引用次数: 0
摘要
背景：一些研究表明肥胖与胎盘早剥谱系（PAS）之间存在显著关联，而另一些研究则没有相关报道。因此，我们进行了一项荟萃分析，以探讨肥胖与 PAS 风险之间的关联：为了通过观察性研究探讨肥胖与 PAS 之间的关联，我们在 PubMed、Web of Science、Google scholar 和 Scopus 数据库中进行了系统检索，检索时间截至 2024 年 3 月 30 日。荟萃分析采用随机效应模型，使用纽卡斯尔-渥太华量表评估纳入研究的质量。使用Stata软件14版（StataCorp，College Station，Texas，USA），显著性水平小于0.05被认为具有统计学意义：在粗略研究中，肥胖与 PAS 风险之间的关系具有显著性（1.51 [95% CI: 1.19, 1.82; I 2 = 0.0%]）。然而，在调整后的研究中，两者之间的关系并不显著（1.25 [95% CI: 0.45, 2.05; I 2 = 52.0%]）：这些研究结果表明，肥胖可能与较高的 PAS 风险有关，这在粗略研究中尤为明显。然而，要进一步阐明这种关系，必须开展具有较大样本量的前瞻性队列研究，并对混杂变量进行细致的控制。
Obesity and risk of placenta accreta spectrum: A meta-analysis.
Background: Some studies have indicated a notable association between obesity and placenta accreta spectrum (PAS), while others have not reported. Hence, we performed a meta-analysis to explore the association between obesity and the risk of PAS.
Methods: To explore the association between obesity and PAS through observational studies, we conducted a systematic search across PubMed, Web of Science, Google scholar, and Scopus databases up to March 30, 2024. The meta-analysis utilized a random-effect model, with the quality of included studies assessed using the Newcastle-Ottawa scale. A significance level of less than 0.05 was considered statistically significant using Stata software, version 14 (StataCorp, College Station, TX, USA).
Results: The association between obesity and PAS risk in crude studies showed significance (1.51 [95% CI: 1.19, 1.82; I2 = 0.0%]). However, in adjusted studies, the association was not significant (1.25 [95% CI: 0.45, 2.05; I2 = 52.0%]).
Conclusion: These findings suggest that obesity has been proposed as potentially associated with a higher risk of PAS, particularly evident in crude studies. However, it is imperative to conduct prospective cohort studies with a large sample size and meticulous control of confounding variables to further elucidate this relationship.
期刊介绍：
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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