Lori Ranallo, Harsh B Pathak, Jianghua He, Jaromme Geebum Kim, Karla Van Goethem, Karin Denes-Collar, Julia Danielle Caldwell, Jamie S Myers
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Feasibility Study of Adverse Childhood Experiences, Treatment-Related Sequelae, and Inflammatory Markers in Breast Cancer Survivors.
Objectives: To explore the incidence of adverse childhood experiences (ACEs) in breast cancer survivors and potential associations with long-term treatment-related sequelae.
Sample & setting: English-speaking breast cancer survivors three or more years from diagnosis with complete treatment response (N = 120) were recruited prior to scheduled survivorship clinic visits.
Methods & variables: Participants in this cross-sectional observational feasibility study rated anxiety, depression, fatigue, sleep disturbance, cognitive issues, resilience, and ACEs (experienced prior to age 18 years). Blood samples were analyzed for inflammatory and epigenetic biomarkers.
Results: ACEs assessment was feasible. Higher ACE scores correlated with greater fatigue, anxiety, and depression, and with lower cognitive function (p < 0.05). Resilience was positively associated with cognitive function and negatively associated with fatigue, anxiety, and depression.
Implications for nursing: There is evidence for the impact of ACEs on long-term treatment-related sequelae in women with breast cancer. Oncology nurses should consider incorporating ACEs assessment into the workflow for women receiving survivorship care.
期刊介绍：
The mission of the Oncology Nursing Forum, an official publication of ONS, is to
Convey research information related to practice, technology, education, and leadership.
Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care.
Stimulate discussion of critical issues relevant to oncology nursing.
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