清除废物塑造老年大脑健康

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2024-10-08 DOI:10.1016/j.neuron.2024.09.017

Li-Feng Jiang-Xie, Antoine Drieu, Jonathan Kipnis

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引用次数: 0

摘要

大脑的健康与液体流动动态密切相关，液体流动动态可以清除大脑中潜在的有害废物。这一系统受血管动态、血管周围空间的维持、睡眠时的神经活动以及脑膜层淋巴引流的调节。然而，衰老会影响上述每一层的调节，导致大脑清洁功能受损，出现各种与年龄相关的神经系统疾病，包括阿尔茨海默氏症和帕金森氏症。了解脑内液体流动调节的复杂性以及这种调节是如何随着年龄的增长而发生改变的，可以揭示新的靶点和治疗策略，从而解决与年龄相关的神经系统衰退问题。

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Waste clearance shapes aging brain health.

Brain health is intimately connected to fluid flow dynamics that cleanse the brain of potentially harmful waste material. This system is regulated by vascular dynamics, the maintenance of perivascular spaces, neural activity during sleep, and lymphatic drainage in the meningeal layers. However, aging can impinge on each of these layers of regulation, leading to impaired brain cleansing and the emergence of various age-associated neurological disorders, including Alzheimer's and Parkinson's diseases. Understanding the intricacies of fluid flow regulation in the brain and how this becomes altered with age could reveal new targets and therapeutic strategies to tackle age-associated neurological decline.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.