基于性别的重度抑郁障碍首发药物依赖者灰质体积差异及其分子分析。

IF 1.6 4区 医学 Q4 NEUROSCIENCES
Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-10-10 DOI:10.1097/WNR.0000000000002107
Duo Sun, Kang Xi, Runxu Yang, Jiangmin Chu, Mingjie Xu, Dafu Zhang, Yuqi Cheng
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引用次数: 0

摘要

本研究分析了重度抑郁障碍(MDD)患者的灰质体积(GMV)是否存在性别差异,并探讨了这些差异与神经递质系统之间的关系。这项研究共招募了190名首次发病、未服用过药物的重度抑郁症患者和293名健康对照者。所有参与者都接受了 T1 加权高分辨率磁共振成像检查。研究分析了诊断(健康对照组 vs. MDD)和性别(男性 vs. 女性)在 GMV 改变方面的相互作用。JuSpace 工具箱涵盖了广泛的神经递质系统,被用来确定 MDD 引起的和性别引起的 GMV 改变与大脑中特定受体/转运蛋白之间的关系。在健康对照组中观察到了性别特异性 GMV 差异,但在 MDD 患者中没有观察到。与女性健康对照组相比,男性健康对照组在双侧海马旁、舌、枕下、纺锤形、小脑亚区和左颞下的 GMV 更大,但女性健康对照组丘脑几个亚区的 GMV 比男性健康对照组更大。性别引起的 GMV 改变与 5- 羟色胺受体亚型 1a、大麻素受体和多巴胺受体有关(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gray matter volume differences based on sex in first-episode drug-naive patients with major depressive disorder and its molecular analysis.

This study analyzed whether gray matter volume (GMV) differences exist between the sexes in patients with major depressive disorder (MDD) and explored the relationships between these differences and neurotransmitter systems. This study enrolled 190 first-episode drug-naive patients with MDD and 293 healthy controls. All participants underwent T1-weighted high-resolution MRI. The interaction between the diagnosis (healthy controls vs. MDD) and sex (male vs. female) regarding GMV alterations was analyzed. The JuSpace toolbox, which covers a wide range of neurotransmitter systems, was used to identify the relationship between MDD-induced and sex-induced GMV alterations and specific receptor/transporter proteins in the brain. Sex-specific GMV differences were observed in the healthy controls but not in MDD patients. Male healthy controls had a larger GMV in the bilateral parahippocampal, lingual, inferior occipital, fusiform, cerebellar subregions, and left inferior temporal than female healthy controls, but several subregions of the thalamus had a larger GMV in female healthy controls than in male healthy controls. Sex-induced GMV alterations were associated with 5-hydroxytryptamine receptor subtype 1a, cannabinoid receptor, and dopamine receptor ( P  < 0.01, false discovery rate corrected). GMV differences were not detected in the main effect of diagnosis and the interaction of diagnosis and sex. Sex-specific GMV differences are associated with the spatial distribution of serotonin, dopamine, and cannabinoid neurotransmitter receptor systems. Sex-based physiological differences in the GMV may account for male and female susceptibility to and differences in the clinical symptoms of MDD.

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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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