以体育锻炼和睡眠取代久坐行为对中风风险的影响：一项前瞻性队列研究。

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-10-13 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S482276

Xiao-Fang Dong, Qiang Zhang, Jia-Ning Wei, Qian-Yu Zhou, Fan-Jia-Yi Yang, Yan-Jin Liu, Yu-Sheng Li, Chang-Qing Sun

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引用次数: 0

摘要

研究目的我们的研究探讨了闲暇时间久坐行为（SB）与中风风险的相关性。此外，我们还利用等时替代模型（ISM）来研究用轻度体力活动（LPA）、中度体力活动（MPA）、剧烈体力活动（VPA）和睡眠来替代短暂的闲暇时间久坐行为会如何影响中风风险：这项调查跟踪了英国生物库中的 478,198 名参与者。通过标准化问卷收集了有关个人闲暇时间SB和PA的数据。结果：我们发现了 10,003 例中风病例：结果：在 12.7 年的时间里，我们发现了 10,003 例中风病例。与每天进行休闲时间体育锻炼少于 4 小时的参与者相比，休闲时间体育锻炼时间越长，中风发病率的危险比（HRs）越高：4-6 小时/天的危险比为 1.06（95% CI：1.01-1.11），6-8 小时/天的危险比为 1.16（95% CI：1.10-1.23），8 小时以上的危险比为 1.24（95% CI：1.15-1.33）。根据 ISM 分析，用各种形式的 PA 替代休闲时间的 SB 可显著降低中风风险。对于睡眠时间≤8 小时/天的人来说，用同等时间的 LPA、VPA 或睡眠来替代一小时的闲暇时间 SB，可使卒中风险分别降低 3.0%、7.0% 和 22.0%。同时，对于那些睡眠时间已超过 8 小时/天的人群，用同等时间的 LPA 或 VPA 代替 1 小时的闲暇时间 SB，可使脑卒中风险分别显著降低 6.0% 和 18.0%：研究结果表明，闲暇时间SB和不健康的睡眠时间是中风的确证风险因素。对于每天睡眠时间为 8 小时或不足 8 小时的人以及睡眠时间超过 8 小时的人来说，分别用充足的睡眠时间或参与 VPA 来替代休闲时间睡眠是降低中风风险的有效策略。

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Impact of Replacing Sedentary Behavior with Physical Activity and Sleep on Stroke Risk: A Prospective Cohort Study.

Objective: Our research explores how leisure-time sedentary behavior (SB) correlates with stroke risk. Additionally, we utilize the isotemporal substitution model (ISM) to examine how replacing brief durations of leisure-time SB with light physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep might influence the risk of stroke.

Methods: This investigation tracked 478,198 participants from the UK Biobank. Data regarding individual leisure-time SB and PA were collected through a standardized questionnaire. A Cox proportional hazards model, alongside an isotemporal substitution model (ISM), was utilized.

Results: We identified 10,003 cases of incident stroke over 12.7 years. When compared to participants who engaged in leisure-time SB for less than 4 hours per day, the hazard ratios (HRs) for stroke incidence increased with more prolonged leisure-time SB: HRs were 1.06 (95% CI: 1.01 to 1.11) for 4-6 h/d, 1.16 (95% CI: 1.10 to 1.23) for 6-8 h/d, and 1.24 (95% CI: 1.15 to 1.33) for over 8 h/d. According to the ISM analysis, substituting leisure-time SB with various forms of PA could markedly reduce stroke risk. For individuals sleeping ≤8h/d, replacing one hour of leisure-time SB with an equivalent duration of LPA, VPA, or sleep corresponded to a 3.0%, 7.0%, and 22.0% decrease in stroke risk, respectively. Meanwhile, for those already sleeping more than 8h/d, substituting one hour of leisure-time SB with an equivalent duration of LPA or VPA resulted in a notable decrease in the risk of stroke by 6.0% and 18.0%, respectively.

Conclusion: The findings demonstrate that leisure-time SB and unhealthy sleep durations are confirmed risk factors for stroke. For individuals sleeping 8 hours or less per day, and for those who sleep more than 8 hours, substituting SB with an adequate amount of sleep or engaging in VPA, respectively, emerges as an effective strategy for reducing stroke risk.

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.