Jiaqi Yang, Lauren Bernard, Kari E Wong, Bing Yu, Lyn M Steffen, Valerie K Sullivan, Casey M Rebholz
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引用次数: 0
摘要
简介:临床重要饮食(如地中海-DASH 神经退行性延迟干预(MIND)饮食)缺乏生物标志物:临床上缺乏重要饮食的生物标志物,如地中海-DASH 神经退行性延迟干预饮食(MIND):我们的研究探讨了与坚持 MIND 饮食相关的血清代谢物:在 3908 名社区动脉粥样硬化风险(ARIC)研究参与者中,我们根据 66 项自我报告的食物频率问卷(FFQ)计算出了修改后的 MIND 饮食评分。修改后的得分不包括浆果和橄榄油,因为这些项目没有在 FFQ 中进行评估。我们在 ARIC 研究参与者的 2 个亚组中使用了多变量线性回归模型,并使用固定效应回归对结果进行了元分析,以确定经过 Bonferroni 校正后的重要代谢物。我们还研究了这些代谢物与改良 MIND 饮食中的食物成分之间的关联。C统计量评估了利用参与者特征之外的重要代谢物对改良MIND饮食高依从性的预测:结果:在分析的 360 种代谢物中,27 种代谢物(15 种阳性,12 种阴性)与改良 MIND 饮食评分显著相关(脂类,n = 13;氨基酸,n = 5;异种生物,n = 3;辅因子和维生素,n = 3;碳水化合物,n = 2;核苷酸,n = 1)。能提高对改良 MIND 膳食高膳食依从性预测的前 4 种代谢物是 7-甲基黄嘌呤、可可碱、二十二碳六烯酸酯(DHA)和 3-羧基-4-甲基-5-丙基-2-呋喃丙酸酯(CMPF):有 27 个代谢组标记物与改良 MIND 饮食相关。这些生物标志物如能得到进一步验证,将有助于客观评估MIND饮食的坚持情况。
Serum metabolite signature of the modified Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet.
Introduction: There is a lack of biomarkers of clinically important diets, such as the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet.
Objectives: Our study explored serum metabolites associated with adherence to the MIND diet.
Methods: In 3,908 Atherosclerosis Risk in Communities (ARIC) study participants, we calculated a modified MIND diet score based on a 66-item self-reported food frequency questionnaire (FFQ). The modified score did not include berries and olive oil, as these items were not assessed in the FFQ. We used multivariable linear regression models in 2 subgroups of ARIC study participants and meta-analyzed results using fixed effects regression to identify significant metabolites after Bonferroni correction. We also examined associations between these metabolites and food components of the modified MIND diet. C-statistics evaluated the prediction of high modified MIND diet adherence using significant metabolites beyond participant characteristics.
Results: Of 360 metabolites analyzed, 27 metabolites (15 positive, 12 negative) were significantly associated with the modified MIND diet score (lipids, n = 13; amino acids, n = 5; xenobiotics, n = 3; cofactors and vitamins, n = 3; carbohydrates n = 2; nucleotide n = 1). The top 4 metabolites that improved the prediction of high dietary adherence to the modified MIND diet were 7-methylxanthine, theobromine, docosahexaenoate (DHA), and 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF).
Conclusion: Twenty-seven metabolomic markers were correlated with the modified MIND diet. The biomarkers, if further validated, could be useful to objectively assess adherence to the MIND diet.
期刊介绍:
Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to:
metabolomic applications within man, including pre-clinical and clinical
pharmacometabolomics for precision medicine
metabolic profiling and fingerprinting
metabolite target analysis
metabolomic applications within animals, plants and microbes
transcriptomics and proteomics in systems biology
Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.