Zhe Xu, Hong Li, Guojie Cao, Panpan Li, Haitao Zhou, Yang Sun
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引用次数: 0
摘要
急性心肌梗死（AMI）和相关心血管疾病并发症是全球死亡的主要原因。棕色脂肪组织（BAT）具有生热作用，其特点是表达解偶联蛋白。最新研究发现，在心血管疾病中，活化的棕色脂肪组织可通过细胞间通讯有效改善急性心肌梗死和并发心力衰竭的预后。然而，人们对 BAT 在急性心肌梗死后的心肌保护机制，尤其是 BAT 的内分泌功能还缺乏清晰而系统的认识。本综述介绍了 BAT 对急性心肌梗死后心脏中各种细胞的影响。在缺血/再灌注（I/R）、心肌重塑和心肌纤维化过程中，BAT 对心脏细胞和成纤维细胞起着保护作用。本综述还讨论了在心力衰竭的不同阶段 BAT 激活所引起的变化。最后，本综述总结了针对 BAT 的治疗方法，以改善急性心肌梗死。要阐明 BAT 与心脏组织中不同细胞之间联系的内在机制，以确定潜在的治疗靶点，还需要进一步的深入研究。
The protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure.
Acute myocardial infarction (AMI) and related cardiovascular disease complications are the leading causes of mortality worldwide. Brown adipose tissue (BAT) is thermogenic and characterized by the uncoupling protein expression. Recent studies have found that in cardiovascular diseases, activated BAT can effectively improve the prognosis of AMI and concurrent heart failure through intercellular communication. However, a clear and systematic understanding of the myocardial protective mechanism of BAT after AMI is lacking, especially in the endocrine function of BAT. This review describes the effects of BAT on various cells in the heart after AMI. BAT plays a protective role on cardiac cells and fibroblasts during ischemia/reperfusion (I/R), myocardial remodeling, and myocardial fibrosis. This review also discusses the changes caused by BAT activation in different stages of heart failure. Finally, this review summarizes the treatment methods that target BAT to improve AMI. Further in-depth researches are still needed to clarify the underlying mechanism of the connection between BAT and different cells in cardiac tissue in order to identify potential therapeutic targets.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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