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引用次数: 0
摘要
深部脑刺激（DBS），包括光刺激和电刺激，已被证明在探索病理脑活动和开发神经疾病治疗方法方面具有相当大的价值。以植入式微电极阵列（MEA）探针为基础的深部脑刺激微系统的进步为原位闭环深部脑刺激（CL-DBS）带来了新的机遇。这项技术可用于检测受损的大脑回路，并同时测试调节这些回路输出对多种疾病的治疗潜力。尽管基于 MEA 探针的 CL-DBS 微型系统取得了成功并得到了快速应用，但包括过度有线通信在内的关键挑战仍亟待解决。在这篇综述中，我们探讨了基于 MEA 探针的无线 CL-DBS 微型系统的最新进展，并概述了这一领域的主要问题和广阔前景。这项技术有可能在未来为精神疾病提供新的治疗方案。
Wireless closed-loop deep brain stimulation using microelectrode array probes.
Deep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously. Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems, key challenges, including excessive wired communication, need to be urgently resolved. In this review, we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field. This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.
期刊介绍：
Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community.
JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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