接受富马酸二甲酯治疗的脱髓鞘疾病患者出现非典型播散性带状疱疹感染。

IF 2.3 4区医学 Q3 NEUROSCIENCES

Journal of NeuroVirology Pub Date : 2024-10-21 DOI:10.1007/s13365-024-01230-x

Alexandra Balshi, John Dempsey, Jacob A Sloane

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引用次数: 0

摘要

我们报告了两名在接受富马酸二甲酯（DMF）治疗期间发生非典型、播散性带状疱疹感染的患者，其中一人患有水痘带状疱疹病毒（VZV）脑炎，另一人患有带状疱疹耳炎，导致了持久的运动和感觉障碍。我们建议将在开始使用 DMF 之前接种 VZV 疫苗作为标准护理措施，因为确保患者在开始使用 DMF 之前接种 VZV 疫苗可以预防此类严重后果的发生。

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Atypical disseminated herpes zoster infections in patients with demyelinating disease treated with dimethyl fumarate.

We report two patients who developed atypical, disseminated herpes zoster infections while on dimethyl fumarate (DMF) treatment, one with varicella zoster virus (VZV) encephalitis and another with herpes zoster oticus resulting in lasting motor and sensory deficits. We recommend vaccination against VZV prior to DMF initiation be incorporated as standard of care, as ensuring patients are protected against VZV before starting DMF can prevent such severe outcomes.

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来源期刊

Journal of NeuroVirology 医学-病毒学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.