食用麦芽汁对肠道微生物群的影响:基于肠型的初步研究

IF 3.3 4区 生物学 Q2 MICROBIOLOGY
Journal of Microbiology Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI:10.1007/s12275-024-00176-3
Gyungcheon Kim, Seongok Kim, Hayan Jung, Seohyun Kang, Gwoncheol Park, Hakdong Shin
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引用次数: 0

摘要

麦芽汁是一种传统的韩国白酒,含有乳酸菌和膳食纤维等成分,可引起肠道微生物组的变化。由于微生物组的反应在肠型之间可能存在差异--肠型是根据肠道中的主要细菌种群进行分类的,因此我们假设,食用麦芽汁会导致健康参与者肠道微生物结构的肠型依赖性差异。本研究旨在通过将所有参与者分为两个肠型组来确定食用玛奇朵对肠道微生物结构的影响:乳酸杆菌主导型(B 型,n = 7)和普雷沃特菌主导型(P 型,n = 4)。B 型肠道菌群的阿尔法多样性有所增加,而 P 型肠道菌群的阿尔法多样性在食用麦芽汁后没有明显变化。B 型肠道微生物群的组成发生了显著变化,而 P 型在食用玛琪奥利后没有观察到明显变化。值得注意的是,只有 P 型肠道微生物群中的 Prevotella 发生了最显著的变化。与普雷沃特氏菌数量增加相一致的是,与碳水化合物代谢相关的基因,包括戊糖/葡萄糖醛酸盐相互转化、果糖/甘露糖代谢、淀粉/蔗糖代谢和氨基糖/核苷酸糖代谢,在食用玛酷后在 P 型中明显富集。这些研究结果表明,食用玛奇朵后,肠道微生物组成和代谢途径会发生肠型依赖性改变,这凸显了个性化膳食干预的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Impact of Makgeolli Consumption on Gut Microbiota: An Enterotype-Based Preliminary Study.

Makgeolli, a traditional Korean liquor, contains components such as lactic acid bacteria and dietary fiber, which can induce changes in the gut microbiome. Since variations in microbiome responses may exist between enterotypes-classifications based on the dominant bacterial populations in the gut-we hypothesized that the consumption of makgeolli leads to enterotype-dependent differences in gut microbial structures among healthy participants. This study aimed to determine the effect of makgeolli consumption on gut microbial structures by stratifying all participants into two enterotype groups: Bacteroides-dominant type (B-type, n = 7) and Prevotella-dominant type (P-type, n = 4). The B-type showed an increase in alpha diversity, while no significant difference was observed in the P-type following makgeolli consumption. The composition of gut microbiota significantly changed in the B-type, whereas no noticeable alteration was observed in the P-type after makgeolli consumption. Notably, Prevotella exhibited the most significant changes only in the P-type. In line with the increased abundance of Prevotella, the genes associated with carbohydrate metabolism, including pentose/glucuronate interconversions, fructose/mannose metabolism, starch/sucrose metabolism and amino sugar/nucleotide sugar metabolism were significantly enriched following makgeolli consumption in the P-type. These findings suggest that makgeolli consumption induces enterotype-dependent alterations in gut microbial composition and metabolic pathways, highlighting the potential for personalized dietary interventions.

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来源期刊
Journal of Microbiology
Journal of Microbiology 生物-微生物学
CiteScore
5.70
自引率
3.30%
发文量
0
审稿时长
3 months
期刊介绍: Publishes papers that deal with research on microorganisms, including archaea, bacteria, yeasts, fungi, microalgae, protozoa, and simple eukaryotic microorganisms. Topics considered for publication include Microbial Systematics, Evolutionary Microbiology, Microbial Ecology, Environmental Microbiology, Microbial Genetics, Genomics, Molecular Biology, Microbial Physiology, Biochemistry, Microbial Pathogenesis, Host-Microbe Interaction, Systems Microbiology, Synthetic Microbiology, Bioinformatics and Virology. Manuscripts dealing with simple identification of microorganism(s), cloning of a known gene and its expression in a microbial host, and clinical statistics will not be considered for publication by JM.
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