Akkermansia muciniphila 在胰岛素抵抗中的作用

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Zhijun Zeng, Mengjie Chen, Yimin Liu, Yun Zhou, Hongning Liu, Shaohua Wang, Yanhua Ji
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引用次数: 0

摘要

胰岛素抵抗(IR)是多种代谢性疾病的致病因素之一。肠道微生物群在维持肠道屏障功能和人体整体健康方面发挥着至关重要的作用,从而对胰岛素抵抗产生影响。肠道微生物菌群失调可导致 IR 的发生。因此,保持平衡和多样化的肠道微生物群对实现最佳健康至关重要。Akkermansia muciniphila 是一种广泛存在于人体肠道中的微生物,已被证明可以调节胃肠道粘膜屏障的完整性、减少内毒素的渗透、降低全身炎症水平并改善胰岛素敏感性。粘多糖酵母菌数量的减少与胰岛素抵抗和其他代谢性疾病风险的增加有关,这突出表明了粘多糖酵母菌与胰岛素抵抗的相关性。了解粘多糖的作用和调控机制对于理解红外发病机制以及开发预防和治疗相关代谢疾病的新策略至关重要。不同个体的肠道微生物群组成及其对 IR 的影响可能存在个体差异。进一步研究 A. muciniphila 与 IR 之间的个体差异将促进个性化医疗的发展,促进基于肠道微生物群组成的定制干预,这是优化胰岛素敏感性同时预防代谢性疾病发生的一个潜在的未来方向。在这篇综述中,我们描述了粘毛蝇的生理特征,强调了它在导致红外病理的潜在机制中的作用,并总结了其丰度的改变如何影响红外的发展,从而为进一步研究粘毛蝇以及开发针对糖尿病的新药提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Akkermansia muciniphila in insulin resistance.

Insulin resistance (IR) is a pathogenic factor in numerous metabolic diseases. The gut microbiota plays a crucial role in maintaining the function of the intestinal barrier and overall human health, thereby influencing IR. Dysbiosis of the gut microbiota can contribute to the development of IR. Therefore, it is essential to maintain a balanced and diverse gut microbiota for optimal health. Akkermansia muciniphila, a widely present microorganism in the human intestine, has been shown to regulate gastrointestinal mucosal barrier integrity, reduce endotoxin penetration, decrease systemic inflammation levels, and improve insulin sensitivity. Reduced abundance of A. muciniphila is associated with an increased risk of IR and other metabolic diseases, highlighting its correlation with IR. Understanding the role and regulatory mechanism of A. muciniphila is crucial for comprehending IR pathogenesis and developing novel strategies for preventing and treating related metabolic disorders. Individual variations may exist in both the gut microbiota composition and its impact on IR among different individuals. Further investigation into individual differences between A. muciniphila and IR will facilitate advancements in personalized medicine by promoting tailored interventions based on the gut microbiota composition, which is a potential future direction that would optimize insulin sensitivity while preventing metabolic disease occurrence. In this review, we describe the physiological characteristics of A. muciniphila, emphasize its roles in underlying mechanisms contributing to IR pathology, and summarize how alterations in its abundance affect IR development, thereby providing valuable insights for further research on A. muciniphila, as well as new drug development targeting diabetes.

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来源期刊
CiteScore
7.90
自引率
2.40%
发文量
326
审稿时长
2.3 months
期刊介绍: Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.
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