PRMT5：拼接耐受性。

IF 13.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of Clinical Investigation Pub Date : 2024-10-15 DOI:10.1172/JCI185701

Rathan Kumar, Parvathi Ranganathan

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引用次数: 0

摘要

胸腺内组织限制性抗原（TRAs）的表达对自我耐受的建立至关重要；然而，事实证明，TRAs 表达的确切调控机制比以前所认识到的要复杂得多。在本期 JCI 杂志上，Muro 等人发现了蛋白精氨酸甲基转移酶 5 (PRMT5) 在转录后调控 TRAs 以及中枢耐受中的核心作用。作者利用条件性 KO 小鼠表明，胸腺缺乏 Prmt5 会使小鼠易患自身免疫性疾病，同时提高抗肿瘤效果。这些研究深入揭示了 PRMT5 在形成 T 细胞库中的作用，对开发疗法具有重要意义。

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PRMT5: splicing up tolerance.

Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance. Using conditional KO mice, the authors showed that thymic deficiency of Prmt5 predisposed mice to developing autoimmune diseases while enhancing antitumor efficacy. These studies provide insight into the role of PRMT5 in shaping the T cell repertoire with implications for the development of therapies.

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来源期刊

Journal of Clinical Investigation 医学-医学：研究与实验

CiteScore

24.50

自引率

1.30%

发文量

1034

审稿时长

2 months

期刊介绍： The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.