多动症、自闭症和心血管疾病之间的因果关系:两步双样本孟德尔随机调查。

IF 2.7 3区 医学 Q2 PSYCHIATRY
Journal of Attention Disorders Pub Date : 2025-01-01 Epub Date: 2024-10-14 DOI:10.1177/10870547241288741
Zequn Zheng, Dihui Cai
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引用次数: 0

摘要

背景:尽管观察性研究已证实注意缺陷多动障碍(ADHD)、自闭症谱系障碍(ASD)与心血管疾病(CVD)风险增加之间存在联系,但其因果关系尚未明确。本研究旨在探讨自闭症谱系障碍(ASD)、多动症(ADHD)与心血管疾病风险之间的因果关系,并研究多动症(ADHD)和自闭症谱系障碍(ASD)影响心血管疾病的中介因素:利用双样本孟德尔随机化(MR)方法和大规模 GWAS 总结统计,我们研究了 ASD 和 ADHD 与心血管疾病风险之间的潜在因果关系。分析表明,ADHD 与冠心病(OR [95% CI] 1.12 [1.03, 1.21],p = .008)、心力衰竭(OR [95% CI] 1.14 [1.07, 1.22],p = 1.45 × 10-4)和大动脉中风(OR [95% CI] 1.35 [1.09, 1.66],p = .005)的发病可能性增加有关。同时,ASD 与更高的心房颤动风险(OR [95% CI] 1.09 [1.03, 1.16],p = .005)和心力衰竭(OR [95% CI] 1.11 [1.04, 1.19],p = .004)相关。此外,我们还通过两步MR和多变量MR探讨了心血管疾病风险因素的中介作用,强调了吸烟、处方阿片类药物使用、甘油三酯、教育、收入、汤森剥夺指数和肥胖在ADHD、ASD与心血管疾病的因果关系中可能发挥的作用:这项磁共振研究强调了对心血管进行严格监测和干预的必要性,以通过预防已确定的中介风险因素来减少多动症或 ASD 患者的不良心血管事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causality Between ADHD, ASD, and CVDs: A Two-Step, Two-Sample Mendelian Randomization Investigation.

Background: While observational studies have established a connection between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and heightened risk for cardiovascular diseases (CVD), the causal relationships are not well-defined. This study is designed to examine the causality between ASD, ADHD, and CVD risk as well as investigate the mediating factors through which ADHD and ASD influence CVD.

Methods and results: Leveraging two-sample Mendelian randomization (MR) approaches and large scale GWAS summary stats, we examined underlying causal links between ASD and ADHD and the risk of CVDs. The analysis indicated that ADHD was related to an increased likelihood of developing coronary heart disease (OR [95% CI] 1.12 [1.03, 1.21], p = .008), heart failure (OR [95% CI] 1.14 [1.07, 1.22], p = 1.45 × 10-4), and large-artery stroke (OR [95% CI] 1.35 [1.09, 1.66], p = .005). In parallel, ASD showed a correlation with a greater atrial fibrillation risk (OR [95% CI] 1.09 [1.03, 1.16], p = .005] and heart failure (OR [95% CI] 1.11 [1.04, 1.19], p = .004). Additionally, we explored the mediating role of CVD risk factors through two-step MR and multivariable MR, highlighting the possible role of smoking, prescription opioid use, triglycerides, education, income, Townsend deprivation index, and obesity in the causal association of ADHD, ASD, on CVDs.

Conclusion: This MR study highlights the necessity for rigorous cardiovascular surveillance and interventions to decrease adverse cardiovascular events in people with ADHD or ASD by preventing identified mediating risk factors.

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来源期刊
CiteScore
7.60
自引率
6.70%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.
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