胡芦巴种子干提取物补充剂对 2 型糖尿病患者血糖指数、血脂状况和原生质-抗氧化剂平衡的影响:双盲随机临床试验

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Fatemeh Chehregosha, Leila Maghsoumi-Norouzabad, Majid Mobasseri, Laleh Fakhr, Ali Tarighat-Esfanjani
{"title":"胡芦巴种子干提取物补充剂对 2 型糖尿病患者血糖指数、血脂状况和原生质-抗氧化剂平衡的影响:双盲随机临床试验","authors":"Fatemeh Chehregosha, Leila Maghsoumi-Norouzabad, Majid Mobasseri, Laleh Fakhr, Ali Tarighat-Esfanjani","doi":"10.34172/jcvtr.33231","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to determine the effects of fenugreek seed dry extract (FDE) on the glycemic indices, lipid profile, and prooxidant-antioxidant balance (PAB) in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>A double-blind randomized clinical trial was carried out on 54 individuals with T2D. Participants were randomly assigned to a FDE group (received 3 tablets containing 335 mg of FDE daily for 8 weeks) or a placebo group (received tablets containing microcrystalline cellulose). Anthropometric indices, physical activity, diet, fasting blood sugar (FBS), serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein (HDL-C), and PAB were assessed.</p><p><strong>Results: </strong>An eight-week intake of 3 tablets containing 335 mg of FDE decreased serum insulin (<i>P</i>=0.016, <i>P</i><0.001), HOMA-IR (<i>P</i>=0.009, <i>P</i><0.001), TG (<i>P</i><0.001, <i>P</i>=0.001), and PAB (<i>P</i><0.001, <i>P</i><0.001) compared to the baseline, in both placebo and intervention groups respectively. TC decreased significantly compared to the baseline in the placebo group (<i>P</i>=0.028), while HDL-C increased in the FDE group compared to the baseline (<i>P</i><0.001) and placebo group (<i>P</i>=0.014).</p><p><strong>Conclusion: </strong>In the present study even though changes of parameters were more in intervention group compared to the control group, we did not observe any significant differences between studied groups except for HDL-C. However, the effects might become apparent with a higher dosage, longer study duration, or a larger sample size compared to the placebo group. Further clinical trials are needed in this regard.</p>","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"16 3","pages":"184-193"},"PeriodicalIF":1.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489642/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effect of Fenugreek seed dry extract supplement on glycemic indices, lipid profile, and prooxidant-antioxidant balance in patients with type 2 diabetes: A double-blind randomized clinical trial.\",\"authors\":\"Fatemeh Chehregosha, Leila Maghsoumi-Norouzabad, Majid Mobasseri, Laleh Fakhr, Ali Tarighat-Esfanjani\",\"doi\":\"10.34172/jcvtr.33231\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study aims to determine the effects of fenugreek seed dry extract (FDE) on the glycemic indices, lipid profile, and prooxidant-antioxidant balance (PAB) in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>A double-blind randomized clinical trial was carried out on 54 individuals with T2D. Participants were randomly assigned to a FDE group (received 3 tablets containing 335 mg of FDE daily for 8 weeks) or a placebo group (received tablets containing microcrystalline cellulose). Anthropometric indices, physical activity, diet, fasting blood sugar (FBS), serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein (HDL-C), and PAB were assessed.</p><p><strong>Results: </strong>An eight-week intake of 3 tablets containing 335 mg of FDE decreased serum insulin (<i>P</i>=0.016, <i>P</i><0.001), HOMA-IR (<i>P</i>=0.009, <i>P</i><0.001), TG (<i>P</i><0.001, <i>P</i>=0.001), and PAB (<i>P</i><0.001, <i>P</i><0.001) compared to the baseline, in both placebo and intervention groups respectively. TC decreased significantly compared to the baseline in the placebo group (<i>P</i>=0.028), while HDL-C increased in the FDE group compared to the baseline (<i>P</i><0.001) and placebo group (<i>P</i>=0.014).</p><p><strong>Conclusion: </strong>In the present study even though changes of parameters were more in intervention group compared to the control group, we did not observe any significant differences between studied groups except for HDL-C. However, the effects might become apparent with a higher dosage, longer study duration, or a larger sample size compared to the placebo group. Further clinical trials are needed in this regard.</p>\",\"PeriodicalId\":15207,\"journal\":{\"name\":\"Journal of Cardiovascular and Thoracic Research\",\"volume\":\"16 3\",\"pages\":\"184-193\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489642/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cardiovascular and Thoracic Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/jcvtr.33231\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular and Thoracic Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jcvtr.33231","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

摘要

引言本研究旨在确定葫芦巴种子干提取物(FDE)对 2 型糖尿病(T2D)患者的血糖指数、血脂状况和原氧化剂-抗氧化剂平衡(PAB)的影响:方法:对 54 名 2 型糖尿病患者进行了双盲随机临床试验。参与者被随机分配到复方脱氢雪腐镰刀菌素组(每天服用 3 片含 335 毫克复方脱氢雪腐镰刀菌素的药片,连续服用 8 周)或安慰剂组(服用含微晶纤维素的药片)。评估内容包括人体测量指数、体力活动、饮食、空腹血糖(FBS)、血清胰岛素、胰岛素抵抗静态模型评估(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和PAB:结果:连续八周服用 3 片含 335 毫克 FDE 的药片,血清胰岛素下降(P=0.016,PP=0.009,PPP=0.001),PAB 下降(PPP=0.028),而与基线相比,FDE 组的 HDL-C 上升(PP=0.014):在本研究中,尽管与对照组相比,干预组的参数变化更大,但除高密度脂蛋白胆固醇外,我们并未观察到研究组之间存在任何显著差异。不过,与安慰剂组相比,如果剂量更大、研究时间更长或样本量更大,效果可能会更明显。在这方面还需要进一步的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of Fenugreek seed dry extract supplement on glycemic indices, lipid profile, and prooxidant-antioxidant balance in patients with type 2 diabetes: A double-blind randomized clinical trial.

Introduction: This study aims to determine the effects of fenugreek seed dry extract (FDE) on the glycemic indices, lipid profile, and prooxidant-antioxidant balance (PAB) in patients with type 2 diabetes (T2D).

Methods: A double-blind randomized clinical trial was carried out on 54 individuals with T2D. Participants were randomly assigned to a FDE group (received 3 tablets containing 335 mg of FDE daily for 8 weeks) or a placebo group (received tablets containing microcrystalline cellulose). Anthropometric indices, physical activity, diet, fasting blood sugar (FBS), serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein (HDL-C), and PAB were assessed.

Results: An eight-week intake of 3 tablets containing 335 mg of FDE decreased serum insulin (P=0.016, P<0.001), HOMA-IR (P=0.009, P<0.001), TG (P<0.001, P=0.001), and PAB (P<0.001, P<0.001) compared to the baseline, in both placebo and intervention groups respectively. TC decreased significantly compared to the baseline in the placebo group (P=0.028), while HDL-C increased in the FDE group compared to the baseline (P<0.001) and placebo group (P=0.014).

Conclusion: In the present study even though changes of parameters were more in intervention group compared to the control group, we did not observe any significant differences between studied groups except for HDL-C. However, the effects might become apparent with a higher dosage, longer study duration, or a larger sample size compared to the placebo group. Further clinical trials are needed in this regard.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Cardiovascular and Thoracic Research
Journal of Cardiovascular and Thoracic Research CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.00
自引率
0.00%
发文量
22
审稿时长
7 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信