将阿育吠陀哲学与现代药物研发技术相结合:亟需深入了解机理,以获得更广泛的可接受性。

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Chavan Sandeep , Vidya Gupta , Vineeta Deshmukh , Sadanand Sardeshmukh
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引用次数: 0

摘要

阿育吠陀是一门整体科学,强调治疗和保持身体的和谐与平衡。来自天然资源的药物和预先确定的剂型是阿育吠陀疗法成功治疗各种疾病(包括癌症等复杂疾病)不可或缺的组成部分。阿育吠陀药物是几种活性植物化合物和/或自然资源的混合体,治疗中不使用分离/提纯的分子。不过,阿育吠陀药物采用各种独特的方法,利用天然介质(如水、脂质、酪乳和柠檬汁等)去除不需要的成分/杂质,提高药物的生物利用度和疗效。需要对原材料、加工过程和最终药物中的此类似是而非的改变、选择和/或特征植物化合物的保留进行研究,以便对产品进行精确的鉴定和分析。因此,为了保证质量的真实性、可靠性和最佳疗效,必须对生产程序进行严格的标准化。此外,由于阿育吠陀药物性质复杂,同时具有多层次和/或多靶点作用,可用于治疗各种功能障碍,因此在临床前和临床研究中了解其机理方面的问题极具挑战性。本文重点介绍了用于癌症等各种简单和复杂疾病及其治疗的阿育吠陀草药和金属矿物药在标准化和表征方面可能面临的挑战和理想的路线图。文章强调,应严格遵守阿育吠陀药的生产程序,并利用先进的制药和分析技术对成品进行彻底表征。此外,还强调需要正式出版详细的专著或档案,包括保质期研究,以传播知识并为全世界所接受。最后,还应在合适的动物模型中进行现代药理学的安全性和有效性研究,以便合理使用这些药物。只有通过合理的实验和合乎伦理的报告,阿育吠陀药物对癌症等可怕疾病的主流或辅助治疗才能取得成效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating Ayurvedic philosophy with modern technologies for drug research and development: A critical need of mechanistic insights for wider acceptability
Ayurveda is a holistic science emphasizing healing and maintaining harmony and balance in the body. Medicines from natural resources and in pre-defined dosage forms are integral parts of successful Ayurvedic treatment in various diseases including complex ailments, such as cancer. Ayurvedic medicines are cocktails of several active phyto-compounds and/or natural resources and no isolated/purified molecules are used in the treatment. However, various unique methods employed using natural media, such as water, lipids, buttermilk, and lemon juice, just to name a few, lead to the elimination of unwanted constituents/impurities and enhance the bioavailability and efficacy of the drug. Such plausible alterations, selection, and/or retention of signature phytocompounds in the raw materials, during the process, and in the final drug need to be studied for precise product identification and analysis. Critical standardization of the manufacturing procedures is, therefore, mandatory for quality fidelity, assurance, and optimum efficacy. Moreover, the simultaneous multi-level and/or multi-targeted actions of Ayurvedic medicines against various dysfunctions due to their complex nature makes it extremely challenging to understand the mechanistic aspects during pre-clinical and clinical studies.
The present article focuses on probable challenges and ideal roadmaps for standardization and characterization of such herbal as well as metallic-mineral Ayurvedic medicines being used for various simple and complex diseases like cancer and their treatments. It is emphasized that Ayurvedic manufacturing procedures should be followed meticulously and the finished product be characterized thoroughly using advanced pharmaceutical and analytical techniques. It is also accentuated that detailed monographs or dossiers including shelf-life studies need to be officially published for knowledge dissemination and worldwide acceptance. Finally, safety and efficacy studies as per modern pharmacology ought to be conducted in suitable animal models for the judicious use of these medicines. Mainstream or adjuvant treatment of dreadful diseases such as cancer with Ayurvedic medicines will only be fruitful through rational experimentation and ethical reporting.
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来源期刊
Journal of Ayurveda and Integrative Medicine
Journal of Ayurveda and Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
4.70
自引率
12.50%
发文量
136
审稿时长
30 weeks
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