堪非醇能协同增强顺铂诱导的结肠癌细胞凋亡和细胞周期停滞。

IF 2.5 Q3 ONCOLOGY
Muhammad Haroon, Sun Chul Kang
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引用次数: 0

摘要

结肠癌仍然是全球关注的重大健康问题,因此需要不断探索新的治疗策略。顺铂是一种一线化疗药物,常用于治疗包括结肠癌在内的多种恶性肿瘤患者。然而,获得性耐药性是其临床应用的一大障碍。本研究调查了山奈酚(一种具有已知抗癌特性的天然类黄酮)与顺铂联合使用对结肠癌细胞的协同作用。我们的研究采用结肠癌细胞系来评估山奈酚和顺铂的单独和联合细胞毒性作用。结果表明,与单独治疗相比,山奈酚和顺铂联合治疗结肠癌细胞的细胞毒性明显增强。这种协同作用的进一步特征是细胞凋亡的增加,这可以从形态学变化以及细胞凋亡和细胞周期的生化指标得到证明。研究发现,联合治疗可调节关键的凋亡通路,包括上调促凋亡因子和下调抗凋亡因子。此外,协同效应还与抑制细胞增殖和诱导细胞周期停滞有关。这项研究的结果表明,山奈酚和顺铂的组合有望成为结肠癌治疗的一种有效治疗策略,有可能在提高传统化疗疗效的同时将不良反应降至最低。为了验证这些研究结果并探索这种协同方法在临床环境中的转化潜力,有必要开展进一步的深入研究,包括体内研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells.

Colon cancer remains a significant global health concern, necessitating the continuous exploration of novel therapeutic strategies. Cisplatin is a first-line chemotherapy medication that is frequently used to treat patients for a variety of malignancies, including colon cancer. However, a major obstacle to its clinical usefulness is acquired resistance. This research investigates the synergistic effects of kaempferol, a natural flavonoid with known anti-cancer properties, in combination with cisplatin, in colon cancer cells. Our study employed colon cancer cell lines to evaluate the individual and combined cytotoxic effects of kaempferol and cisplatin. The results demonstrated a notable enhancement in the cytotoxicity of colon cancer cells when treated with a combination of kaempferol and cisplatin compared to individual treatments. This synergistic effect was further characterized by an increase in apoptosis, as evidenced by morphological changes and biochemical markers of apoptosis and cell cycle. The investigations revealed that the combined treatment led to the modulation of key apoptotic pathways, including the upregulation of pro-apoptotic factors and downregulation of anti-apoptotic factors. Additionally, the synergistic effect was associated with the inhibition of cell proliferation and induction of cell cycle arrest. The findings of this study suggest that the combination of kaempferol and cisplatin holds promise as a potent therapeutic strategy for colon cancer treatment, potentially enhancing the efficacy of conventional chemotherapy while minimizing adverse effects. Further in-depth investigations, including in vivo studies, are warranted to validate these findings and explore the translational potential of this synergistic approach in clinical settings.

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