接受非类固醇抗炎药和/或非生理性类固醇治疗的狗有可能出现严重的胃肠道溃疡。

IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES
Townes N Hillier, Meghan M Watt, Janet A Grimes, Alexia N Berg, Justin A Heinz, Vanna M Dickerson
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引用次数: 0

摘要

动物:33 只狗报告接受非甾体抗炎药和/或皮质类固醇治疗的狗的胃肠道溃疡病变的发生率和特征:回顾多个转诊机构 2012 年 1 月至 2022 年 7 月期间 30 天内接受非甾体抗炎药和/或皮质类固醇治疗的胃肠道溃疡患犬的医疗记录。通过内窥镜检查、手术或尸体解剖确诊。从病历中收集临床数据,包括服用非甾体抗炎药或类固醇的剂量和原因:犬只接受了一种非甾体抗炎药(n = 22,最常见的是卡洛芬[9]、美洛昔康[4]和德拉克昔布[3])、两种非甾体抗炎药(5)、一种类固醇(5:泼尼松龙[2]、泼尼松[2]或地塞米松SP[1])或一种非甾体抗炎药和类固醇(1)。有 11 只狗接受了适当剂量的单一环氧化酶 (COX)-2 保护型非甾体抗炎药,但出现了溃疡。所有同时服用两种非甾体抗炎药的狗都出现了全层穿孔(5 只中有 5 只)。最常见的溃疡部位是十二指肠(18 只)和幽门(11 只)。腹部超声波检查正确确定了 24 只狗中 5 只的溃疡部位:临床意义:以推荐剂量服用COX-2抑制型非甾体抗炎药的狗有可能出现严重的消化道溃疡。卡洛芬是最常见的导致溃疡的非甾体抗炎药,但它也是处方量最大的非甾体抗炎药之一。添加另一种非甾体抗炎药和类固醇可能会增加这种风险。对于服用非甾体抗炎药的狗来说,无论服用时间长短,仔细观察都是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dogs receiving cyclooxygenase-2-sparing nonsteroidal anti-inflammatory drugs and/or nonphysiologic steroids are at risk of severe gastrointestinal ulceration.

Objective: To report the incidence and characteristics of gastrointestinal ulceration lesions in dogs receiving an NSAID and/or corticosteroid.

Animals: 33 dogs.

Clinical presentation: Medical records of dogs with gastrointestinal ulceration receiving NSAIDs and/or corticosteroids within 30 days of diagnosis between January 2012 and July 2022 at multiple referral institutions were reviewed. Diagnosis was confirmed via endoscopy, surgery, or necropsy. Clinical data were collected from the medical record, including the dose and reason for administration of NSAIDs or steroids.

Results: Dogs received a single NSAID (n = 22, most commonly carprofen [9], meloxicam [4], and deracoxib [3]), 2 NSAIDs (5), a single steroid (5: prednisolone [2], prednisone [2], or dexamethasone SP [1]), or an NSAID and steroid (1). Eleven dogs receiving a single cyclooxygenase (COX)-2-sparing NSAID at an appropriate dose had ulcerations. All dogs receiving 2 NSAIDs concurrently experienced full-thickness perforation (5 of 5). The most common ulcer locations were duodenum (n = 18) and pylorus (11). Abdominal ultrasound correctly identified the site of ulceration in 5 of 24 dogs.

Clinical relevance: Dogs receiving COX-2 sparing NSAIDs at recommended doses are at risk of severe GI ulceration. Carprofen was the most common NSAID resulting in ulceration; however, it is one of the most prescribed NSAIDs. Adding another NSAID and steroid could increase this risk. Careful monitoring is crucial for dogs on NSAIDs, regardless of duration.

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来源期刊
CiteScore
1.60
自引率
15.80%
发文量
539
审稿时长
6-16 weeks
期刊介绍: Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.
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