检测和靶向实体瘤的多角度视角。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Abhishek Bhattacharya, Anjan Kr Dasgupta
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引用次数: 0

摘要

实体瘤是最常见的癌症形式。在疾病诊断方面,已经取得了相当大的技术和医学进步。然而,最重要的是早期发现疾病,但这离现实还很遥远。相反,实体瘤的治疗和治疗领域仍处于起步阶段。化疗和放疗等传统治疗方法对健康细胞和癌细胞的影响是不加区分的,这给治疗带来了挑战。因此,高效的药物靶向是实体瘤治疗的关键方法。这包括向癌细胞精确输送药物,同时尽量减少对健康细胞的伤害。靶向药物在抑制肿瘤生长的同时,在消灭癌细胞方面表现出卓越的疗效,并通过优化吸收减轻副作用,从而进一步降低抗药性风险。此外,根据患者的肿瘤特异性分子特征定制靶向疗法可提高疗效,降低复发的可能性。本章讨论了实体瘤的显著特征、早期发现疾病的可能性以及传统方法之外的潜在治疗角度。此外,本章还深入探讨了磁场效应在靶向癌细胞方面迄今未知的特性,即利用正常细胞对磁场的敏感性相对低于癌细胞的特性,这表明磁性纳米粒子在未来具有选择性摧毁癌细胞的潜力。最后,生物信息学工具和其他非常规方法(如人工智能辅助的密码子偏差分析)在理解肿瘤生物学、帮助确定未来靶向疗法方面发挥着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multifaceted perspectives of detecting and targeting solid tumors.

Solid tumors are the most prevalent form of cancer. Considerable technological and medical advancements had been achieved for the diagnosis of the disease. However, detection of the disease in an early stage is of utmost importance, still far from reality. On the contrary, the treatment and therapeutic area to combat solid tumors are still in its infancy. Conventional treatments like chemotherapy and radiation therapy pose challenges due to their indiscriminate impact on healthy and cancerous cells. Contextually, efficient drug targeting is a pivotal approach in solid tumor treatment. This involves the precise delivery of drugs to cancer cells while minimizing harm to healthy cells. Targeted drugs exhibit superior efficacy in eradicating cancer cells while impeding tumor growth and mitigate side effects by optimizing absorption which further diminishes the risk of resistance. Furthermore, tailoring targeted therapies to a patient's tumor-specific molecular profile augments treatment efficacy and reduces the likelihood of relapse. This chapter discuss about the distinctive characteristics of solid tumors, the possibility of early detection of the disease and potential therapeutic angle beyond the conventional approaches. Additionally, the chapter delves into a hitherto unknown attribute of magnetic field effect to target cancer cells which exploit the relatively less susceptibility of normal cells compared to cancer cells to magnetic fields, suggesting a future potential of magnetic nanoparticles for selective cancer cell destruction. Lastly, bioinformatics tools and other unconventional methodologies such as AI-assisted codon bias analysis have a crucial role in comprehending tumor biology, aiding in the identification of futuristic targeted therapies.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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