小儿慢性活动性 Epstein-Barr 病毒感染中 γδ T 细胞的功能障碍。

IF 3.2 3区医学 Q1 PEDIATRICS

Italian Journal of Pediatrics Pub Date : 2024-10-12 DOI:10.1186/s13052-024-01783-x

Junhong Ai, Haijuan Xiao, Linlin Zhang, Honghao Ma, Dong Wang, Dilara Dilmurat, Ran Wang, Zhengde Xie

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引用次数: 0

摘要

慢性活动性爱泼斯坦-巴氏病毒感染（CAEBV）是一种进行性和危及生命的疾病，其特点是持续或反复的 EBV 激活。据报道，γδ T 细胞是一种细胞毒性淋巴细胞，在限制 EBV 方面发挥着关键作用。然而，γδ T 细胞在小儿 CAEBV 患者中的功能状态尚未得到描述。本研究通过流式细胞术分析，探讨了 CAEBV 患者中 γδ T 细胞产生细胞因子的能力。研究发现，CAEBV 患者体内γδ T 细胞的频率降低，细胞溶解分子颗粒酶 B 的表达减少，这表明该疾病中γδ T 细胞的免疫调节功能失调。

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Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection.

Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.

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来源期刊

Italian Journal of Pediatrics PEDIATRICS-

CiteScore

6.10

自引率

13.90%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.