动脉硬化患者动脉硬化血管的分布及不同部位血清脂质水平的差异

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S483324

Weiyong Xu, Zhenchang Wang, Huaqing Yao, Zifeng Zeng, Xinping Lan

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引用次数: 0

摘要

目的研究单部位动脉硬化和多部位动脉硬化（≥2条动脉明显硬化）患者的动脉硬化血管分布、血清脂质谱的差异以及血脂异常比例的差异：从医院病历系统中提取了 6581 名单部位动脉硬化患者和 5940 名多部位动脉硬化患者的数据。收集并分析单部位动脉硬化患者和多部位动脉硬化患者的血清总胆固醇（TC）、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白（Apo）A1、ApoB 浓度和 C 反应蛋白（CRP）：病变最多的动脉是冠状动脉（7099 人，33.7%）、肢端动脉（6546 人，31.1%）和颈动脉（5279 人，25.1%）。与单部位动脉硬化患者相比，多部位动脉硬化患者的 TC、LDL-C、TC/HDL-C 和 LDL-C/HDL-C 水平较高，CRP 水平较低。非老年人的 TC、LDL-C 水平（结论：多部位动脉硬化患者的血清脂质水平与单部位动脉硬化患者存在差异：不同年龄、性别和动脉硬化血管分布的动脉硬化患者血清脂质水平存在差异。

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Distribution of Arteriosclerotic Vessels in Patients with Arteriosclerosis and the Differences of Serum Lipid Levels Classified by Different Sites.

Objective: To investigate the distribution of arteriosclerotic vessels of arteriosclerosis, differential serum lipid profiles, and differences in the proportion of dyslipidaemia between patients with single-site arteriosclerosis and multi-site arteriosclerosis (significant hardening of ≥2 arteries).

Methods: The data of 6581 single-site arteriosclerosis patients and 5940 multi-site arteriosclerosis patients were extracted from the hospital medical record system. Serum total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) A1, ApoB concentrations and C-reactive protein (CRP) between patients with single-site arteriosclerosis and multi-site arteriosclerosis were collected and analyzed.

Results: The most diseased arteries were coronary arteries (n=7099, 33.7%), limb arteries (n=6546, 31.1%), and carotid arteries (n=5279, 25.1%). TC, LDL-C, TC/HDL-C, and LDL-C/HDL-C levels were higher and CRP level was lower in multi-site arteriosclerosis patients than those in single-site arteriosclerosis patients. The TC, LDL-C levels in non-elderly (<65 years old) female patients were higher and TG/HDL-C, TC/HDL-C, LDL-C/HDL-C levels were lower than those in non-elderly male patients, while the TG, TC, LDL-C, and TG/HDL-C levels in elderly (≥65 years old) female patients were higher and LDL-C/HDL-C level was lower than those in elderly male patients. The proportion of dyslipidemia in descending order was as follows: low HDL-C (31.9%), elevated TG (16.9%), elevated TC (9.0%), and elevated LDL-C (4.2%). The levels of TC, LDL-C, TC/HDL-C, and LDL-C/HDL-C in patients with peripheral arteriosclerosis were higher than those in patients with cardio-cerebrovascular arteriosclerosis.

Conclusion: There were differences in serum lipid levels in patients with arteriosclerosis with different age, gender and distribution of arteriosclerotic vessels.

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.