坦桑尼亚纳曼加和穆图库拉边境蚊子中黄热病病毒的血清流行率和分子分析。

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Remidius Kamuhabwa Kakulu , Josephine Vitus Kapinga , Sima Rugarabamu , Elison Kemibala , Medard Beyanga , Peter M. Mbelele , Khalid Massa , Esther Gwae Kimaro , Emmanuel Abraham Mpolya
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引用次数: 0

摘要

目的:黄热病(YF)是一个主要的公共卫生问题,尤其是在非洲和南美洲。本研究旨在检测人类和蚊子样本中的 YF,以了解坦桑尼亚-乌干达和坦桑尼亚-肯尼亚跨境地区的传播动态:方法:采集 9 个月及以上儿童的血样进行血清学检测,同时捕获蚊子并检测 YF 病毒 RNA。采用逻辑回归模型预测血清流行率和相关风险因素:YF血清总流行率为12.5%,老年人(7.0%)和女性(IgG 4.4%,IgM 6.0%)的流行率较高。值得注意的是,在 46 个蚊子池的 192 只蚊子中,有 3 只检测到了 YF 病毒 RNA。与受过高等教育的人相比,受过小学教育的人检测出 YF IgG 阳性的几率较低(AOR = 0.27,CI:0.08-0.88),而女性检测出 YF IgG 阳性的几率较高(AOR = 4.7,CI:1.5-14.7)。7)、前往 YF 流行地区(AOR = 5.2,CI:1.35-44.75)、接触伊蚊(AOR = 3.7,CI:1.27-10.84)、经历肌肉疼痛(AOR = 4.5,CI:1.08-18.78)和出现瘀伤(AOR = 13.5,CI:1.23-145.72):结论:尽管坦桑尼亚没有暴发逸蝇疫情,但有证据表明在所研究的边境地区存在逸蝇暴露,这突出表明有必要加强跨境监测、病媒控制、疫苗接种和进一步研究,以评估国家的整体逸蝇风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence and molecular analysis of yellow fever virus in mosquitoes at Namanga and Mutukula borders in Tanzania

Objectives

Yellow fever (YF) is a major public health concern, particularly in Africa and South America. This study aimed to detect YF in human and mosquito samples to understand transmission dynamics in the Tanzania–Uganda and Tanzania–Kenya cross-border areas.

Methods

Blood samples were collected from individuals aged ≥9 months for serological testing. Mosquitoes were captured and tested for YF virus RNA. Logistic regression models were used to predict seroprevalence and associated risk factors.

Results

The overall YF seroprevalence was 12.5%, with higher rates among older individuals (7.0%) and female participants (immunoglobulin [Ig] G 4.4%, IgM 6.0%). Notably, YF virus RNA was detected in three out of 46 pools of 192 mosquitoes. The odds of testing positive for YF IgG were lower among those with primary education compared with college education (AOR = 0.27, CI: 0.08-0.88) and increased with those experiencing muscle pain (AOR = 4.5, CI: 1.08-18.78) while the odds of testing positive to YF IgM increased with being female (AOR = 4.7, CI: 1.5-14.7), traveling to YF endemic areas (AOR = 5.2, CI: 1.35-44.75), exposure to Aedes mosquitoes (AOR = 3.7, CI: 1.27-10.84) and exhibiting bruising (AOR = 13.5, CI: 1.23-145.72)

Conclusions

Although Tanzania has not experienced YF outbreaks, evidence of YF exposure at the studied borders highlights the need for strengthening cross-border surveillance, vector control, and vaccination efforts. Further research is needed to evaluate the country's overall YF risks.
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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