在非人类灵长类动物中施用空气传播的病原体。

IF 2 4区 医学 Q4 TOXICOLOGY
Inhalation Toxicology Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI:10.1080/08958378.2024.2412685
Justina R Creppy, Benoit Delache, Julien Lemaitre, Branka Horvat, Laurent Vecellio, Frédéric Ducancel
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引用次数: 0

摘要

目的:空气中的病原体扫描可穿透人体呼吸道并导致疾病。因此,使用动物模型预测气溶胶沉积和研究呼吸道疾病的病理生理学对研究非常重要,也是测试和研究治疗作用机制的先决条件。非人类动物在解剖结构、呼吸参数和免疫系统方面与人类相似,因此是吸入研究的相关动物物种:本综述旨在概述在非人灵长类动物(NHPs)中进行的病原体气溶胶研究的最新进展。在此,我们介绍并讨论了气溶胶细菌和病毒的沉积。在这篇综述中,我们介绍了使用非人灵长类动物作为吸入研究模型的重要优势:结果:我们证明,气溶胶在呼吸道中的沉积不仅是气溶胶大小的函数,而且给药技术也会影响气溶胶的生物活性和沉积部位。最后,我们观察到病原体在呼吸道的沉积区域对非自然人病理生理效应的发展有影响:结论:向 NHP 呼吸道投放病原体的方法多种多样,其剂量和在呼吸道中的沉积情况也各不相同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Administration of airborne pathogens in non-human primates.

Purpose: Airborne pathogen scan penetrate in human respiratory tract and can cause illness. The use of animal models to predict aerosol deposition and study respiratory disease pathophysiology is therefore important for research and a prerequisite to test and study the mechanism of action of treatment. NHPs are relevant animal species for inhalation studies because of their similarities with humans in terms of anatomical structure, respiratory parameters and immune system.

Materials and methods: The aim of this review is to provide an overview of the state of the art of pathogen aerosol studies performed in non-human primates (NHPs). Herein, we present and discuss the deposition of aerosolized bacteria and viruses. In this review, we present important advantages of using NHPs as model for inhalation studies.

Results: We demonstrate that deposition in the respiratory tract is not only a function of aerosol size but also the technique of administration influences the biological activity and site of aerosol deposition. Finally, we observe an influence of a region of pathogen deposition in the respiratory tract on the development of the pathophysiological effect in NHPs.

Conclusion: The wide range of methods used for the delivery of pathogento NHP respiratory airways is associated with varying doses and deposition profiles in the airways.

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来源期刊
Inhalation Toxicology
Inhalation Toxicology 医学-毒理学
CiteScore
4.10
自引率
4.80%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Inhalation Toxicology is a peer-reviewed publication providing a key forum for the latest accomplishments and advancements in concepts, approaches, and procedures presently being used to evaluate the health risk associated with airborne chemicals. The journal publishes original research, reviews, symposia, and workshop topics involving the respiratory system’s functions in health and disease, the pathogenesis and mechanism of injury, the extrapolation of animal data to humans, the effects of inhaled substances on extra-pulmonary systems, as well as reliable and innovative models for predicting human disease.
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